How COVID-19 can be simulated in 3D cell culture

被引：0
|
作者：
Wilflingseder D. [1 ]
Posch W. [1 ]
机构：
[1] Institut für Hygiene und Medizinische Mikrobiologie, Medizinische Universität Innsbruck, Schöpfstraße 41/R311, Innsbruck
来源：
BIOspektrum | 2022年 / 28卷 / 1期
关键词：
D O I：
10.1007/s12268-022-1712-y
中图分类号：
学科分类号：
摘要：
Excessive inflammation triggered by a hitherto undescribed mechanism is a hallmark of severe SARS-CoV-2 infection and is associated with enhanced pathogenicity and mortality. Complement hyper activation promotes lung injury and was observed in patients suffering from MERS-CoV, SARS-CoV-1 and SARS-CoV-2 infections. To evaluate the very first interactions of SARS-CoV-2 patient isolates with human epithelial tissues, 3D models of the human respiratory tract as well as lung organoids are highly suitable. © 2022, Die Autorinnen und Autoren.
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页码：43 / 46
页数：3
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