Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Patients with Esophageal Adenocarcinoma: Results from a Phase 1 Cohort

被引:0
|
作者
Benjamin Tan
Adnan Khattak
Enriqueta Felip
Karen Kelly
Patricia Rich
Ding Wang
Christoph Helwig
Isabelle Dussault
Laureen S. Ojalvo
Nicolas Isambert
机构
[1] Washington University School of Medicine,Vall d’Hebron University Hospital, Vall d’Hebron Institute of Oncology (VHIO)
[2] Fiona Stanley Hospital,undefined
[3] IOB-Quiron,undefined
[4] UVic-UCC,undefined
[5] University of California Davis Comprehensive Cancer Center,undefined
[6] Cancer Treatment Centers of America,undefined
[7] Piedmont Healthcare,undefined
[8] Henry Ford Cancer Institute,undefined
[9] Merck KGaA,undefined
[10] EMD Serono Research & Development Institute,undefined
[11] Inc.,undefined
[12] An affiliate of Merck KGaA,undefined
[13] Poitiers University Hospital,undefined
来源
Targeted Oncology | 2021年 / 16卷
关键词
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:435 / 446
页数:11
相关论文
共 50 条
  • [11] PHASE 1 EVALUATION OF BINTRAFUSP ALFA (M7824), A BIFUNCTIONAL FUSION PROTEIN TARGETING TGF-β AND PD-L1, IN CERVICAL CANCER
    Allan, S.
    Braiteh, F.
    Calvo Aller, E.
    Cervantes, A.
    Edenfield, W.
    Li, T.
    Rasschaert, M.
    Park-Simon, T-W
    Longo, F.
    Paz-Ares, L.
    Spira, A.
    Strauss, J.
    Ojalvo, L. S.
    Helwig, C.
    Dussault, I.
    Gulley, J. L.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2019, 29 : A72 - A73
  • [12] Phase I study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with pretreated biliary tract cancer
    Yoo, Changhoon
    Oh, Youn
    Choi, Hye Jin
    Kudo, Masatoshi
    Ueno, Makoto
    Kondo, Shunsuke
    Chen, Li-Tzong
    Osada, Motonobu
    Helwig, Christoph
    Dussault, Isabelle
    Ikeda, Masafumi
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (01)
  • [13] Evaluation of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in cervical cancer: Data from phase 1 and phase 2 studies.
    Strauss, Julius
    Braiteh, Fadi S.
    Calvo, Emiliano
    De Miguel, Maria
    Cervantes, Andres
    Edenfield, William Jeffery
    Li, Tianhong
    Rasschaert, Marika Anna
    Park-Simon, Tjoung-Won
    Longo, Federico
    Paz-Ares, Luis G.
    Spira, Alexander I.
    Jehl, Genevieve
    Dussault, Isabelle
    Ojalvo, Laureen S.
    Gulley, James L.
    Allan, Suzanne Wendy
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [14] Phase II study of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in platinum-experienced advanced cervical cancer
    Birrer, M. J.
    Mileshkin, L. R.
    Fujiwara, K.
    Ray-Coquard, I.
    Alexandre, J.
    Okamoto, A.
    Mirza, M. R.
    Gulley, J. L.
    Jehl, G.
    Ramage, S.
    Ojalvo, L. S.
    Campos, S. M.
    ANNALS OF ONCOLOGY, 2020, 31 : S644 - S645
  • [15] Model-informed approach for risk management of bleeding toxicities for bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1
    Yulia Vugmeyster
    Ana-Marija Grisic
    Justin J. Wilkins
    Anja H. Loos
    Roland Hallwachs
    Motonobu Osada
    Karthik Venkatakrishnan
    Akash Khandelwal
    Cancer Chemotherapy and Pharmacology, 2022, 90 : 369 - 379
  • [16] Model-informed approach for risk management of bleeding toxicities for bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1
    Vugmeyster, Yulia
    Grisic, Ana-Marija
    Wilkins, Justin J.
    Loos, Anja H.
    Hallwachs, Roland
    Osada, Motonobu
    Venkatakrishnan, Karthik
    Khandelwal, Akash
    CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2022, 90 (04) : 369 - 379
  • [17] Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in advanced squamous cell carcinoma of the head and neck: results from a phase I cohort (vol 8, e000664, 2020)
    Cho, B. C.
    Daste, A.
    Ravaud, A.
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 (02)
  • [18] Safety and Tolerability of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGFβ and PD-L1, in Asian Patients with Pretreated Recurrent or Refractory Gastric Cancer
    Kang, Yoon-Koo
    Bang, Yung-Jue
    Kondo, Shunsuke
    Chung, Hyun Cheol
    Muro, Kei
    Dussault, Isabelle
    Helwig, Christoph
    Osada, Motonobu
    Doi, Toshihiko
    CLINICAL CANCER RESEARCH, 2020, 26 (13) : 3202 - 3210
  • [19] Long-term follow-up of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with pretreated biliary tract cancer
    Yoo, C.
    Oh, D-Y.
    Choi, H. J.
    Kudo, M.
    Ueno, M.
    Kondo, S.
    Chen, L-T.
    Osada, M.
    Helwig, C.
    Dussault, I.
    Ikeda, M.
    ANNALS OF ONCOLOGY, 2020, 31 : S268 - S269
  • [20] Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses
    Lan, Yan
    Yeung, Tsz-Lun
    Huang, Hui
    Wegener, Ansgar A.
    Saha, Somdutta
    Toister-Achituv, Mira
    Jenkins, Molly H.
    Chiu, Li-Ya
    Lazorchak, Adam
    Tarcic, Ohad
    Wang, Hong
    Qi, Jin
    Locke, George
    Kalimi, Doron
    Qin, Guozhong
    Marelli, Bo
    Yu, Huakui
    Gross, Alec W.
    Derner, Melissa G.
    Soloviev, Maria
    Botte, Mathieu
    Sircar, Aroop
    Ma, Hong
    Sood, Vanita D.
    Zhang, Dong
    Jiang, Feng
    Lo, Kin-Ming
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 (07)