Chiral separation of β2-agonists by capillary electrophoresis using hydroxypropyl-α-cyclodextrin as a chiral selector

被引：0

作者：

Kyeong Ho Kim

Hyun Ju Kim

Eun Young Jeun

Sang Hun Seo

Seon-Pyo Hong

Jong-Seong Kang

Jeong-Rok Youm

Sang Cheal Lee

机构：

[1] Kangwon National University,College of Pharmacy

[2] Kyung Hee University,College of Pharmacy

[3] Chungnam National University,College of Pharmacy

[4] Chung Ang University,College of Pharmacy

[5] Kangwon National University,College of Pharmacy

来源：

Archives of Pharmacal Research | 2001年 / 24卷

关键词：

Capillary electrophoresis; Chiral separation; Hydroxypropyi-β-cyclodextrin; β; -agonist;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Enantiomers of five racemic β2-agonists were investigated by capillary electrophoresis employing a hydroxypropyl-β-cyclodextrin (HP-β-CD). The effects of the concentration of HP-β-CD added to the background electrolyte and of the pH of the buffer on the effective mobility and resolution of the studied compounds were examined. Very good resolution was achieved for terbutaline and clenbuterol; salbutamol and bambuterol was able to be partially resolved. Enantioselectivity and resolution were influenced by the concentration of the HP-β-CD, buffer composition and pH.

引用

页码：281 / 285

页数：4

共 50 条

[1] Chiral separation of β2-agonists by capillary electrophoresis using hydroxypropyl-α-cyclodextrin as a chiral selector
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