Chiral separation of β2-agonists by capillary electrophoresis using hydroxypropyl-α-cyclodextrin as a chiral selector

被引：12
|
作者：
Kim, KH
Kim, HJ
Jeun, EY
Seo, SH
Hong, SP
Kang, JS
Youm, JR
Lee, SC
机构：
[1] Kangwon Natl Univ, Coll Pharm, Kangwon Do, South Korea
[2] Kyung Hee Univ, Coll Pharm, Seoul, South Korea
[3] Chungnam Natl Univ, Coll Pharm, Taejon, South Korea
[4] Chung Ang Univ, Coll Pharm, Seoul 156756, South Korea
来源：
ARCHIVES OF PHARMACAL RESEARCH | 2001年 / 24卷 / 04期
关键词：
capillary electrophoresis; chiral separation; hydroxypropyl-beta-cyclodextrin; beta(2)-agonist;
D O I：
10.1007/BF02975092
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Enantiomers of five racemic beta (2)-agonists were investigated by capillary electrophoresis employing a hydroxypropyl-beta -cyclodextrin (HP-beta -CD). The effects of the concentration of HP-beta -CD added to the background electrolyte and of the pH of the buffer on the effective mobility and resolution of the studied compounds were examined. Very good resolution was achieved for terbutaline and clenbuterol; salbutamol and bambuterol was able to be partially resolved. Enantioselectivity and resolution were influenced by the concentration of the HP-beta -CD, buffer composition and pH.
引用
收藏
页码：281 / 285
页数：5
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