Peroxisome proliferator–activated receptor-δ attenuates colon carcinogenesis

被引：0

作者：

Fred S Harman

Christopher J Nicol

Holly E Marin

Jerrold M Ward

Frank J Gonzalez

Jeffrey M Peters

机构：

[1] The Pennsylvania State University,Department of Veterinary Science and The Center for Molecular Toxicology and Carcinogenesis

[2] University Park,undefined

[3] Graduate Program in Biochemistry,undefined

[4] Microbiology,undefined

[5] and Molecular Biology,undefined

[6] The Pennsylvania State University,undefined

[7] University Park,undefined

[8] Laboratory of Metabolism,undefined

[9] National Cancer Institute,undefined

[10] Veterinary and Tumor Pathology Section,undefined

[11] Office of Laboratory Animal Resources,undefined

[12] National Cancer Institute,undefined

来源：

Nature Medicine | 2004年 / 10卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Peroxisome proliferator–activated receptor-δ (PPAR-δ; also known as PPAR-β) is expressed at high levels in colon tumors, but its contribution to colon cancer is unclear. We examined the role of PPAR-δ in colon carcinogenesis using PPAR-δ-deficient (Ppard−/− ) mice. In both the Min mutant and chemically induced mouse models, colon polyp formation was significantly greater in mice nullizygous for PPAR-δ. In contrast to previous reports suggesting that activation of PPAR-δ potentiates colon polyp formation, here we show that PPAR-δ attenuates colon carcinogenesis.

引用

页码：481 / 483

页数：2

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