Engineering dendritic cell vaccines to improve cancer immunotherapy

被引：0
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作者：
Caleb R. Perez
Michele De Palma
机构：
[1] École Polytechnique Fédérale de Lausanne (EPFL),Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences
来源：
Nature Communications | / 10卷
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摘要：
At the interface between the innate and adaptive immune system, dendritic cells (DCs) play key roles in tumour immunity and hold a hitherto unrealized potential for cancer immunotherapy. Here we review the role of distinct DC subsets in the tumour microenvironment, with special emphasis on conventional type 1 DCs. Integrating new knowledge of DC biology and advancements in cell engineering, we provide a blueprint for the rational design of optimized DC vaccines for personalized cancer medicine.
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