The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA

被引：0
|
作者：
Zhiqiang Zhang
Musheng Bao
Ning Lu
Leiyun Weng
Bin Yuan
Yong-Jun Liu
机构：
[1] Baylor Institute for Immunology Research,Department of Immunology
[2] Baylor Research Institute,undefined
[3] USA,undefined
[4] Center for Cancer Immunology Research,undefined
[5] University of Texas MD Anderson Cancer Center,undefined
来源：
Nature Immunology | 2013年 / 14卷
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学科分类号：
摘要：
The intracellular sensor DDX41 is important for generating innate responses to DNA viruses. Liu et al. demonstrate that the ubiquitin ligase TRIM21 degrades and thereby regulates DDX41-dependent responses.
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页码：172 / 178
页数：6
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