Selective mutation in ATP-binding site reduces affinity of drug to the kinase: a possible mechanism of chemo-resistance

被引:0
|
作者
Nuzhat N. Kabir
Julhash U. Kazi
机构
[1] KN Biomedical Research Institute,Laboratory of Computational Biochemistry
[2] Lund University,Experimental Clinical Chemistry, Department of Laboratory Medicine
来源
Medical Oncology | 2013年 / 30卷
关键词
Kinase Domain; Important Residue; Selective Mutation; Individual Residue; Eukaryotic Protein Kinase;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 30 条
  • [21] Computational binding affinity and molecular dynamic characterization of annonaceous acetogenins at nucleotide binding domain (NBD) of multi-drug resistance ATP-binding cassette sub-family B member 1 (ABCB1)
    Manoharan, Jeevitha Priya
    Nirmala Karunakaran, Kavinkumar
    Vidyalakshmi, Subramanian
    Dhananjayan, Karthik
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2023, 41 (03): : 821 - 832
  • [22] c-MET tyrosine kinase inhibitors reverse drug resistance mediated by the ATP-binding cassette transporter B1 (ABCB1) in cancer cells
    Nazari, Somayeh
    Poustforoosh, Alireza
    Paul, Priyanka Rani
    Kukreti, Ritushree
    Tavakkoli, Marjan
    Saso, Luciano
    Firuzi, Omidreza
    Moosavi, Fatemeh
    3 BIOTECH, 2025, 15 (01)
  • [23] Uncovering the Mechanism of Drug Resistance Caused by the T790M Mutation in EGFR Kinase From Absolute Binding Free Energy Calculations
    Zhou, Huaxin
    Fu, Haohao
    Liu, Han
    Shao, Xueguang
    Cai, Wensheng
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2022, 9
  • [24] Overexpression of ATP-binding cassette transporter ABCG2 mediates acquired resistance LDC000067, a selective inhibitor of cyclin-dependent kinase CDK9
    Lin, Ming-Lu
    Wu, Chung-Pu
    FASEB JOURNAL, 2016, 30
  • [25] A POINT MUTATION AT THE PUTATIVE ATP-BINDING SITE OF PROTEIN-KINASE C-ALPHA ABOLISHES THE KINASE-ACTIVITY AND RENDERS IT DOWN-REGULATION-INSENSITIVE - A MOLECULAR LINK BETWEEN AUTOPHOSPHORYLATION AND DOWN-REGULATION
    OHNO, S
    KONNO, Y
    AKITA, Y
    YANO, A
    SUZUKI, K
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1990, 265 (11) : 6296 - 6300
  • [26] The serine/threonine kinase Pim-1 promotes drug resistance mediated by the ATP-binding cassette multidrug resistance protein breast cancer resistance protein (BCRP, ABCG2) by stabilizing higher-order BCRP multimers
    Natarajan, Karthika
    Burcu, Mehmet
    Baer, Maria R.
    CANCER RESEARCH, 2011, 71
  • [27] Rationalization of the selective inhibition of VEGF-tyrosine kinase by the angiogenesis inhibitor, PTK787/ZK222584 (1) on the basis of shape complementarity to hydrophobic domains within the ATP-binding site.
    Manley, PW
    Bold, G
    Cozens, R
    Furet, P
    Hofmann, F
    Mestan, J
    Wood, JM
    CLINICAL CANCER RESEARCH, 1999, 5 : 3781S - 3781S
  • [28] Effect of Dual-Targeting MiR-4282 and ATP-Binding Cassette Sub-Family C Member 4 on Drug Resistance o Breast Cancer Cells and Its Molecular Mechanism
    Zhao, Jie
    Jiang, Guoqin
    JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING, 2020, 10 (04) : 507 - 511
  • [29] Substituting c-Jun N-terminal kinase-3 (JNK3) ATP-binding site amino acid residues with their p38 counterparts affects binding of JNK- and p38-selective inhibitors
    Fricker, M
    LoGrasso, P
    Ellis, S
    Wilkie, N
    Hunt, P
    Pollack, SJ
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2005, 438 (02) : 195 - 205
  • [30] Impaired 2′,3′-dideoxy-3′-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11
    Turriziani, O
    Schuetz, JD
    Focher, F
    Scagnolari, C
    Sampath, J
    Adachi, M
    Bambacioni, F
    Riva, E
    Antonelli, G
    BIOCHEMICAL JOURNAL, 2002, 368 (01) : 325 - 332