Essential roles of EphrinB2 in mammalian heart: from development to diseases

被引：0
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作者：
Sheng-an Su
Yao Xie
Yuhao Zhang
Yutao Xi
Jie Cheng
Meixiang Xiang
机构：
[1] The Second Affiliated Hospital,Department of Cardiology
[2] Zhejiang University School of Medicine,undefined
[3] Texas Heart Institute,undefined
来源：
Cell Communication and Signaling | / 17卷
关键词：
EphrinB2; Bidirectional signaling; Development; Cardiac remodeling; Therapeutic molecules;
D O I：
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学科分类号：
摘要：
EphrinB2, a membrane-tethered ligand preferentially binding to its receptor EphB4, is ubiquitously expressed in all mammals. Through the particular bidirectional signaling, EphrinB2 plays a critical role during the development of cardiovascular system, postnatal angiogenesis physiologically and pathologically, and cardiac remodeling after injuries as an emerging role. This review highlights the pivotal involvement of EphrinB2 in heart, from developmental cardiogenesis to pathological cardiac remodeling process. Further potential translational therapies will be discussed in targeting EphrinB2 signaling, to better understand the prevention and treatment of cardiovascular diseases.
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