Thermal Characterization of Gliclazide/β-Cyclodextrin Inclusion Complexes

Gliclazide/β-CD systems were prepared by various techniques: kneading, co-grinding, spray-drying, coprecipitation and neutralization. The thermal behaviour of these systems was studied by using DSC and TG, in order to find occurrence of the occurrence of solid-state inclusion complexation. The use of a complementary technique, Fourier transform infrared spectroscopy (FTIR), was intended to resolve possible ambiguous conclusions from the thermal study. Both studies demonstrated the existence of inclusion complexation in all cases except the kneading technique, which does not lead to a true inclusion complex.