Synthesis, Antibacterial Activity, and Cytotoxicity of Newly Synthesized N-Substituted 5,6-Dimethoxy-1H-indole Derivatives

被引：0

作者：

M. Raghavender

B. Shankar

P. Jalapathi

S. Perugu

机构：

[1] University College of Engineering,Department of Chemistry

[2] Osmania University,Department of Chemistry

[3] University College of Science,Department of Biotechnology

[4] Saifabad,undefined

[5] Osmania University,undefined

[6] National Institute of Technology,undefined

来源：

Russian Journal of General Chemistry | 2019年 / 89卷

关键词：

indole analogues; cytotoxicity; antibacterial activity; molecular docking studies;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

A series of novel functionalized N-substituted 5, 6-dimethoxy-1H-indole derivatives is synthesized. All products are evaluated for antibacterial activity using rifampicin and ciprofloxacin as standard drugs and identified as the promising compounds for further studies. The products are screened for their anticancer activity against MCF7 cell line (breast cancer cell-line) using MTT assay. Two compounds display a significant activity against MCF7 cell line at a very low concentration. The structure-cytotoxicity relationship is supported by molecular docking studies of the active compounds against 3S7S receptor.

引用

页码：1496 / 1501

页数：5

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