Novel Pentaheterocycles. First General Synthesis Entry to Functionalized Derivatives of Pyrido[2,3-f:6,5-f′]di[1,2,4]triazolo[4,3-a] pyrimidin-5(1H)-ones

被引:0
|
作者
Mosselhi A. N. Mosselhi
Magda A. Abdallah
Thoraya A. Farghaly
Ahmad S. Shawali
机构
[1] University of Cairo,Department of Chemistry, Faculty of Science
关键词
Keywords. Hydrazonoyl chlorides; Regiochemistry; Hydrazonothioates; Heterocycles.;
D O I
暂无
中图分类号
学科分类号
摘要
Thirteen derivatives of the novel title ring system were synthesized via a two-step procedure that utilizes hydrazonoyl chlorides and pyridodipyrimidinones as starting materials. The mechanism and regiochemistry of the reactions studied are discussed and the compounds prepared were characterized by alternate synthesis, spectra (mass, IR, 1H and 13C NMR), and elemental analyses.
引用
收藏
页码:211 / 222
页数:11
相关论文
共 50 条
  • [21] Synthesis and antitumor activity of benzo[6",7"] cyclohepta[1",2":4′,5′] pyrido[2′,3′-d] [1,2,4] triazolo[4,3-a]pyrimidin-5-ones
    Edrees, Mastoura M.
    Farghaly, Thoraya A.
    ARABIAN JOURNAL OF CHEMISTRY, 2017, 10 : S1613 - S1618
  • [22] A Facile One-pot Synthesis and Antimicrobial Activity of Pyrido [2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-ones
    Farghaly, Thoraya A.
    Riyadh, Sayed M.
    Abdallah, Magda A.
    Ramadan, Mohamed A.
    ACTA CHIMICA SLOVENICA, 2011, 58 (01) : 87 - 94
  • [23] Structural Elucidation and Antimicrobial Evaluation of Novel [1,2,4]Triazolo[4,3-a]pyrimidines and Pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidinones
    Gomha, Sobhi M.
    Mohamed, Amany M. G.
    Zaki, Yasser H.
    Ewies, Mohamed M.
    Elroby, Shaaban A.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2018, 55 (05) : 1147 - 1156
  • [24] Cellulose Sulfuric Acid as an Eco-Friendly Catalyst for Novel Synthesis of Pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-ones
    Gomha, Sobhi M.
    Riyadh, Sayed M.
    JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2015, 26 (05) : 916 - 923
  • [25] Synthesis and antitumor screening of new 1,7-diphenyl-3-(1,3-disubstituted-1H-pyrazole-4-carbonyl)-[1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones
    Ahmad S. Shawali
    Sherif M. Sherif
    Manal A. A. Darwish
    Mahmoud M. El-merzabani
    Archives of Pharmacal Research, 2010, 33 : 55 - 60
  • [26] Synthesis and Antitumor Screening of New 1,7-Diphenyl-3-(1,3-disubstituted-1H-pyrazole-4-carbonyl)-[1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-ones
    Shawali, Ahmad S.
    Sherif, Sherif M.
    Darwish, Manal A. A.
    El-merzabani, Mahmoud M.
    ARCHIVES OF PHARMACAL RESEARCH, 2010, 33 (01) : 55 - 60
  • [27] Synthesis and reactions of 3-[3-(dimethylamino)propenoyl]-1,7-diphenyl[1,2,4]triazolo[4,3-a]pyrimidin-5(1H)-one
    Farghaly, Thoraya A.
    JOURNAL OF CHEMICAL RESEARCH, 2008, (03) : 152 - 156
  • [28] A CONVENIENT SYNTHESIS OF NOVEL [1,2,4]TRIAZOLO[4,3-A][1,5]BENZODIAZEPINE DERIVATIVES
    AVERSA, MC
    FERLAZZO, A
    GIANNETTO, P
    KOHNKE, FH
    SYNTHESIS-STUTTGART, 1986, (03): : 230 - 231
  • [29] Efficient synthesis and In Silico study of some novel pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine derivatives
    Abdelrazek, Fathy M.
    Gomha, Sobhi M.
    Abdel-aziz, Hassan M.
    Farghaly, Mohamed S.
    Metz, Peter
    Abdel-Shafy, Ahmed
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2020, 57 (04) : 1759 - 1769
  • [30] Synthesis of Novel 1,2,4-Triazolo[4,3-a] quinoxaline Derivatives
    Kim, Ho Sik
    Jeong, Won Young
    Lee, Kyong Hwan
    JOURNAL OF THE KOREAN CHEMICAL SOCIETY-DAEHAN HWAHAK HOE JEE, 2005, 49 (04): : 426 - 430