PI3K signalling: the path to discovery and understanding

被引：0
|
作者：
Bart Vanhaesebroeck
Len Stephens
Phillip Hawkins
机构：
[1] Bart Vanhaesebroeck is at the Centre for Cell Signalling,
[2] Barts Cancer Institute,undefined
[3] Queen Mary University of London,undefined
[4] Charterhouse Square,undefined
[5] London EC1M 6BQ,undefined
[6] United Kingdom.,undefined
[7] Len Stephens and Phillip Hawkins are at the Inositide Laboratory,undefined
[8] The Babraham Institute,undefined
[9] Cambridge CB22 3AT,undefined
[10] United Kingdom.,undefined
来源：
Nature Reviews Molecular Cell Biology | 2012年 / 13卷
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摘要：
Phosphoinositide 3-kinase (PI3K) signalling is central in the regulation of cellular function. Here, Vanhaesebroecket al.review the key discoveries that led the identification of the PI3K genes and function to the design of clinical trials with PI3K inhibitors, over a period of less than three decades.
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页码：195 / 203
页数：8
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