Hyperbaric Oxygen Prevents Bacterial Translocation in Rats with Obstructive Jaundice

被引:0
|
作者
Mehmet L. Akin
Cengiz Erenoglu
Ahmet Dal
Ali Erdemoglu
Emin Elbuken
Ahmet Batkin
机构
[1] Haydarpasa Training Hospital,Department of General Surgery, Gulhane Military Medical Academy
[2] Haydarpasa Training Hospital,Department of Microbiology, Gulhane Military Medical Academy
[3] Haydarpasa Training Hospital,Department of Underwater Medicine, Gulhane Military Medical Academy
来源
Digestive Diseases and Sciences | 2001年 / 46卷
关键词
Obstructive jaundice; bacterial translocation; hyperbaric oxygen;
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学科分类号
摘要
This study was designed to demonstrate bacterial translocation following bile duct ligation and investigate preventive effects of hyperbaric oxygen on obstructive jaundice-related bacterial translocation in an animal model. Hyperbaric oxygen treatment significantly reduced the endogenous colony counts in distal ileum of normal rats both in the short (two days) and long (seven days) term. Endogenous bacteria in distal ileum significantly increased in bile duct ligated rats in the short and long term, and presence of bacterial translocation was proven by bacterial growth in mesenteric lymph nodes, liver, spleen, and blood. Short- and long-term hyperbaric oxygen treatments significantly reduced the intestinal colony counts and prevented the bacterial translocation almost completely in rats with bile duct ligation. It is concluded that obstructive jaundice causes bacterial overgrowth and translocation, and hyperbaric oxygen treatment can prevent both bacterial overgrowth and translocation effectively.
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页码:1657 / 1662
页数:5
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