Sustained release of the antitumor drug paclitaxel from poly(3-hydroxybutyrate)-based microspheres

被引：7
|
作者：
Bonartsev A.P. [1 ,2 ]
Yakovlev S.G. [2 ]
Filatova E.V. [2 ]
Soboleva G.M. [3 ]
Makhina T.K. [2 ]
Bonartseva G.A. [2 ]
Shaitan K.V. [1 ]
Popov V.O. [2 ]
Kirpichnikov M.P. [1 ]
机构：
[1] School of Biology, Lomonosov Moscow State University, Leninskie Gory 1/12, Moscow
[2] Bakh Institute of Biochemistry, Russian Academy of Sciences, Moscow
[3] Joint Stock Company Institute of Engineering Immunology, Lubuchany
来源：
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry | 2012年 / 6卷 / 1期
关键词：
antitumor; microspheres; paclitaxel; poly(3-hydroxybutyrate); sustained release;
D O I：
10.1134/S1990750812010027
中图分类号：
学科分类号：
摘要：
The development of sustained release formulations based on biodegradable polymers is a promising trend in modern pharmacology. Polyhydroxyalkanoates (PHA) attract increasing attention due to their biodegradability and high biocompatibility, which make them suitable for the development of novel drug dosage forms. We have produced poly(3-hydroxybutyrate) (PHB)-based microspheres loaded with the antitumor drug paclitaxel and investigated morphology, drug release kinetics and the effect of these microspheres on tumor cells in vitro. The data on the kinetics of drug release, biocompatibility and biological activity of the biopolymer microspheres in vitro have demonstrated that the studied system of prolonged drug release had lower toxicity and higher efficiency compared to the traditional dosage forms of paclitaxel. © Pleiades Publishing, Ltd., 2012.
引用
收藏
页码：42 / 47
页数：5
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