Synthesis and Anti-HBV Activity of Novel Substituted Pyrimidine Glycosides and Their Acyclic Analogues

被引：0
|
作者：
M. A. Hawata
W. A. El-Sayed
Adel A.-H. Abdel-Rahman
机构：
[1] Menoufia University,Chemistry Department, Faculty of Science
[2] National Research Centre,Photochemistry Department
来源：
Russian Journal of General Chemistry | 2018年 / 88卷
关键词：
pyrimidines; glycosides; acyclic sugars; nucleosides; antiviral; HBV;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
New aryl substituted uracil and thiouracil glycosides are synthesized by glycosylation at N1 in the pyrimidine nucleus using glycopyranosyl halides in basic medium. In addition C-linked hydrazinyl acyclic sugar derivatives exhibiting different sugar moieties, attached at C6, are also prepared. Antiviral activity of the newly synthesized compounds is studied against Hepatitis B virus (HBV). The antiviral tests data indicated high activity of compounds 6b, 6c and 12a–12c with mild cytotoxic effects. The influence of glycosyl moieties attached to the substituted pyrimidine system in addition to the substitution at the aryl fragment on activity is discussed.
引用
收藏
页码：1734 / 1744
页数：10
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