A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families

被引：0
|
作者：
A M Goldstein
L Liu
M G Shennan
D Hogg
M A Tucker
J P Struewing
机构：
[1] National Cancer Institute,Division of Cancer Epidemiology and Genetics
[2] The University of Toronto,Department of Medicine
[3] Toronto-Sunnybrook Regional Cancer Centre,Division of Medical Oncology
[4] The University of Toronto,Department of Medical Biophysics
来源：
British Journal of Cancer | 2001年 / 85卷
关键词：
melanoma; V126D; founder;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
One of the most common melanoma-related CDKN2A mutations reported in North America is the V126D mutation. We examined nine markers surrounding CDKN2A in three American and four Canadian families carrying the V126D mutation. All seven families had a haplotype consistent with a common ancestor/founder for this mutation. In addition, the mutation appears to have originated 34–52 generations ago (1-LOD-unit support interval 13–98 generations). © 2001 Cancer Research Campaign http://www.bjcancer.com
引用
收藏
页码：527 / 530
页数：3
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