Telomeres, p21 and the cancer-aging hypothesis

被引：0
|
作者：
Jessica F Bell
Norman E Sharpless
机构：
[1] The Lineberger Comprehensive Cancer Center,Departments of Medicine and Genetics
[2] The University of North Carolina School of Medicine,undefined
来源：
Nature Genetics | 2007年 / 39卷
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学科分类号：
摘要：
Telomere dysfunction suppresses cancer through the p53 tumor suppressor pathway but also contributes to aging. A new study suggests that these effects of dysfunctional telomeres may be separable, such that aging—but not cancer suppression—depends on the p21 cell cycle inhibitor.
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页码：11 / 12
页数：1
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