Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

被引:0
|
作者
Hao B. [1 ,2 ]
Liu C. [2 ]
Li H. [3 ]
机构
[1] Department of Urology, Tongji Hospital, Huazhong University of Science and Technology
[2] Zhengzhou University
[3] Zhengzhou University
来源
Frontiers of Medicine in China | 2009年 / 3卷 / 2期
关键词
Immunohistochemistry; Phosphatase of regenerating liver 1; Phosphatase of regenerating liver 3; Reverse transcription polymerase chain reaction; Transitional cell carcinoma of bladder;
D O I
10.1007/s11684-009-0036-3
中图分类号
学科分类号
摘要
The mRNA and protein expression of phosphatase of regenerating liver 1 (PRL-1) and phosphatase of regenerating liver 3 (PRL-3) in transitional cell carcinoma of bladder (BTCC) and normal epithelia of bladder was investigated, and the relationship between the BTCC and pathological changes was clarified. The expression of PRL-1 and PRL-3 mRNA was detected by using reverse transcription polymerase chain reaction (RT-PCR) in 30 cases of BTCC and 10 cases of normal bladder, and the expression of PRL-1 and PRL-3 protein was checked by using immunohistochemistry in 30 cases of BTCC and 15 cases of normal bladder. The expression levels of PRL-1 and PRL-3 mRNA and protein were higher in BTCC than those in normal bladder epithelia (P < 0.05). The increased expression of PRL-1 and PRL-3 mRNA and protein was detectable in deep invasion and metastasis of BTCC (P < 0.05). There was no correlation between the expression of PRL-1 and PRL-3 and gender, age or recurrence of BTCC (all P > 0.05). A significantly positive correlation was found between PRL-1 and PRL-3 in BTCC (P < 0.05). PRL-1 and PRL-3 are expressed consistently and may contribute to the growth, differentiation, invasion and metastasis of BTCC. © Higher Education Press and Springer-Verlag GmbH 2009.
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页码:197 / 203
页数:6
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