Development of a multiparameter flow cytometric assay as a potential biomarker for homologous recombination deficiency in women with high-grade serous ovarian cancer

被引:0
|
作者
Jung-Min Lee
Nicolas Gordon
Jane B Trepel
Min-Jung Lee
Minshu Yu
Elise C Kohn
机构
[1] Women’s Malignancies Branch,
[2] Center for Cancer Research,undefined
[3] National Cancer Institute,undefined
[4] Developmental Therapeutics Branch,undefined
[5] Center for Cancer Research,undefined
[6] National Cancer Institute,undefined
关键词
Ovarian cancer; PARP inhibitor; Biomarkers; Flow cytometry; Peripheral blood mononuclear cells; γH2AX; MRE11; RAD51;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [31] Homologous Recombination Deficiency and Cyclin E1 Amplification Are Correlated with Immune Cell Infiltration and Survival in High-Grade Serous Ovarian Cancer
    van Wagensveld, Lilian
    van Baal, Juliette O. A. M.
    Timmermans, Maite
    Gaillard, Duco
    Borghuis, Lauri
    Coffelt, Seth B.
    Rosenberg, Efraim H.
    Lok, Christianne A. R.
    Nijman, Hans W.
    Kooreman, Loes F. S.
    Sanders, Joyce
    de Bruijn, Marco
    Wessels, Lodewyk F. A.
    van der Wiel, Rianne
    Rausch, Christian
    Broeks, Annegien
    Kruitwagen, Roy F. P. M.
    van der Aa, Maaike A.
    Sonke, Gabe S.
    Schouten, Philip C.
    van de Vijver, Koen K.
    Horlings, Hugo M.
    [J]. CANCERS, 2022, 14 (23)
  • [32] HOMOLOGOUS RECOMBINATION DEFICIENCY AND CYCLIN E1 AMPLIFICATION ARE CORRELATED WITH IMMUNE CELL INFILTRATION AND SURVIVAL IN HIGH-GRADE SEROUS OVARIAN CANCER
    Van Wagensveld, Lilian
    Van Baal, Julliete
    Timmermans, Maite
    Gaillard, Duco
    Borghuis, Lauri
    Coffelt, Seth
    Rosenberg, Effraim
    Lok, Christianne
    Nijman, Hans
    Kooreman, Loes
    Broeks, Annegien
    Sanders, Joyce
    De Bruijn, Marco
    Van der Wiel, Rianne
    Kruitwagen, Roy
    Van der Aa, Maaike
    Sonke, Gabe
    Schouten, Philip
    Van de Vijver, Koen
    Horlings, Hugo
    [J]. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2022, 32 : A47 - A47
  • [33] Intratumor heterogeneity and homologous recombination deficiency of high-grade serous ovarian cancer are associated with prognosis and molecular subtypes and change in treatment course.
    Takaya, Hisamitsu
    Nakai, Hidekatsu
    Murakami, Kosuke
    Matsumura, Noriomi
    [J]. CLINICAL CANCER RESEARCH, 2020, 26 (13) : 52 - 52
  • [34] Rates of somatic variants in homologous recombination DNA repair deficiency genes in older patients with high-grade serous ovarian carcinoma
    Pitiyarachchi, Omali
    Lee, Yeh Chen
    Ramus, Susan J.
    deFazio, Anna
    Friedlander, Michael
    [J]. ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, 2022, 18 : 30 - 30
  • [35] T-cell exhaustion is an independent predictive biomarker of clinical outcome in high grade serous ovarian cancer regardless of homologous recombination deficiency status
    Salvioni, Anna
    Del, Mathilde
    Michelas, Marie
    Vuattoux, Pierre
    Scarlata, Clara-Maria
    Martinez-Gomez, Carlos
    Van Acker, Nathalie
    Frenois, Francois-Xavier
    Bataillon, Guillaume
    Delord, Jean-Pierre
    Martinez, Alejandra
    Ayyoub, Maha
    [J]. CANCER RESEARCH, 2024, 84 (05)
  • [36] Association of alterations in homologous recombination repair genes with survival and chemotherapy sensitivity in patients with high-grade serous ovarian cancer
    Khan, Sofia
    Nevanlinna, Heli
    [J]. CANCER RESEARCH, 2012, 72
  • [37] Homologous recombination repair gene mutations show no survival benefits in Chinese high-grade serous ovarian cancer patients
    Feng, Zheng
    Wen, Hao
    Ju, Xingzhu
    Bi, Rui
    Chen, Xiaojun
    Yang, Wentao
    Wu, Xiaohua
    [J]. ANNALS OF TRANSLATIONAL MEDICINE, 2021, 9 (05)
  • [38] Discovery of a biomarker candidate for surgical stratification in high-grade serous ovarian cancer
    Haonan Lu
    Paula Cunnea
    Katherine Nixon
    Natasha Rinne
    Eric O. Aboagye
    Christina Fotopoulou
    [J]. British Journal of Cancer, 2021, 124 : 1286 - 1293
  • [39] Circulating tumour DNA as a diagnostic biomarker in high-grade serous ovarian cancer
    Moore, E.
    Goranova, T.
    Addley, H.
    Piskorz, A.
    Mouliere, F.
    Chandrananda, D.
    Morris, J.
    Ros, S.
    Jimenez-Linan, M.
    Crawford, R.
    Parkinson, C.
    Rosenfeld, N.
    Brenton, J.
    [J]. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2018, 125 (08) : E30 - E30
  • [40] Discovery of a biomarker candidate for surgical stratification in high-grade serous ovarian cancer
    Lu, Haonan
    Cunnea, Paula
    Nixon, Katherine
    Rinne, Natasha
    Aboagye, Eric O.
    Fotopoulou, Christina
    [J]. BRITISH JOURNAL OF CANCER, 2021, 124 (07) : 1286 - 1293