Modulatory Effect of 8-OH-DPAT on Behavior of Ovariectomized Female Rats

被引：0

作者：

N. S. Sapronov

Yu. O. Fedotova

E. I. Malygina

机构：

[1] Russian Academy of Medical Sciences,S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine

来源：

Bulletin of Experimental Biology and Medicine | 2004年 / 137卷

关键词：

8-OH-DPAT; passive avoidance; plus-maze; behavior; estrogens; pharmacotherapy;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Behavior of ovariectomized rats was studied after chronic administration of serotonin 1A receptor agonist 8-OH-DPAT alone or in combination with 17β-estradiol for 14 days. The effect of 8-OH-DPAT on learning was evaluated in the conditioned passive avoidance task. Behavioral activity in elevated plus-maze and open field was recorded. Administration of 8-OH-DPAT to ovariectomized female rats increased the number of entries into open arms of the maze and the time spent there. Combination treatment of ovariectomized animals with 8-OH-DPAT and 17β-estradiol decreased total locomotor and emotional activity in the open field. Administration of 8-OH-DPAT alone or in combination with 17β-estradiol improved performance of the conditioned passive avoidance response.

引用

页码：43 / 46

页数：3

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