Modulatory Effect of 8-OH-DPAT on Behavior of Ovariectomized Female Rats

被引：0
|
作者：
N. S. Sapronov
Yu. O. Fedotova
E. I. Malygina
机构：
[1] Russian Academy of Medical Sciences,S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine
来源：
Bulletin of Experimental Biology and Medicine | 2004年 / 137卷
关键词：
8-OH-DPAT; passive avoidance; plus-maze; behavior; estrogens; pharmacotherapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Behavior of ovariectomized rats was studied after chronic administration of serotonin 1A receptor agonist 8-OH-DPAT alone or in combination with 17β-estradiol for 14 days. The effect of 8-OH-DPAT on learning was evaluated in the conditioned passive avoidance task. Behavioral activity in elevated plus-maze and open field was recorded. Administration of 8-OH-DPAT to ovariectomized female rats increased the number of entries into open arms of the maze and the time spent there. Combination treatment of ovariectomized animals with 8-OH-DPAT and 17β-estradiol decreased total locomotor and emotional activity in the open field. Administration of 8-OH-DPAT alone or in combination with 17β-estradiol improved performance of the conditioned passive avoidance response.
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页码：43 / 46
页数：3
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