A quantitative model of transcription factor–activated gene expression

被引：0
|
作者：
Harold D Kim
Erin K O'Shea
机构：
[1] Howard Hughes Medical Institute,Departments of Molecular and Cellular Biology
[2] and Chemistry and Chemical Biology,undefined
[3] Faculty of Arts and Sciences Center for Systems Biology,undefined
[4] Harvard University,undefined
[5] Northwest Laboratories,undefined
来源：
Nature Structural & Molecular Biology | 2008年 / 15卷
关键词：
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学科分类号：
摘要：
The effect of transcription factor affinity and accessibility on gene expression has been difficult to quantify and model. The contribution of both transcription factor binding affinity and nucleosomes to tuning and diversification of gene expression output is now quantitatively uncovered, and a model that can be applied to other eukaryotic gene expression systems generated.
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页码：1192 / 1198
页数：6
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