Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer

被引：0

作者：

Simon N Stacey

Andrei Manolescu

Patrick Sulem

Steinunn Thorlacius

Sigurjon A Gudjonsson

Gudbjörn F Jonsson

Margret Jakobsdottir

Jon T Bergthorsson

Julius Gudmundsson

Katja K Aben

Luc J Strobbe

Dorine W Swinkels

K C Anton van Engelenburg

Brian E Henderson

Laurence N Kolonel

Loic Le Marchand

Esther Millastre

Raquel Andres

Berta Saez

Julio Lambea

Javier Godino

Eduardo Polo

Alejandro Tres

Simone Picelli

Johanna Rantala

Sara Margolin

Thorvaldur Jonsson

Helgi Sigurdsson

Thora Jonsdottir

Jon Hrafnkelsson

Jakob Johannsson

Thorarinn Sveinsson

Gardar Myrdal

Hlynur Niels Grimsson

Steinunn G Sveinsdottir

Kristin Alexiusdottir

Jona Saemundsdottir

Asgeir Sigurdsson

Jelena Kostic

Larus Gudmundsson

Kristleifur Kristjansson

Gisli Masson

James D Fackenthal

Clement Adebamowo

Temidayo Ogundiran

Olufunmilayo I Olopade

Christopher A Haiman

Annika Lindblom

Jose I Mayordomo

Lambertus A Kiemeney

机构：

[1] deCODE Genetics,Departments of Epidemiology and Biostatistics and Clinical Chemistry and Urology

[2] Sturlugata 8,Department of Surgery

[3] Comprehensive Cancer Centre IKO,Department of Surgery

[4] Radboud University Nijmegen Medical Centre,Department of Preventive Medicine

[5] Canisius Wilhelmina Hospital,Division of Medical Oncology

[6] Slingeland Hospital,Division of Medical Oncology

[7] Keck School of Medicine,Department of Molecular Medicine

[8] University of Southern California,Department of Oncology

[9] Cancer Research Center,Departments of Oncology

[10] University of Hawaii,Department of Medicine and Center for Clinical Cancer Genetics

[11] University Hospital,Division of Oncology, Department of Surgery

[12] Health Science Institute,undefined

[13] Nanotechnology Institute of Aragon,undefined

[14] Ernest Lluch Hospital,undefined

[15] Karolinska Institutet,undefined

[16] Karolinska University Hospital at Södersjukhuset,undefined

[17] Surgery,undefined

[18] and Radiation Physics,undefined

[19] Landspitali-University Hospital,undefined

[20] Clinical Research Centre,undefined

[21] University of Chicago,undefined

[22] College of Medicine,undefined

[23] University of Ibadan,undefined

[24] University College Hospital,undefined

来源：

Nature Genetics | 2008年 / 40卷

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学科分类号：

摘要：

We carried out a genome-wide association study of breast cancer predisposition with replication and refinement studies involving 6,145 cases and 33,016 controls and identified two SNPs (rs4415084 and rs10941679) on 5p12 that confer risk, preferentially for estrogen receptor (ER)-positive tumors (OR = 1.27, P = 2.5 × 10−12 for rs10941679). The nearest gene, MRPS30, was previously implicated in apoptosis, ER-positive tumors and favorable prognosis. A recently reported signal in FGFR2 was also found to associate specifically with ER-positive breast cancer.

引用

页码：703 / 706

页数：3

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