13-Deoxo-13-iminodutomycin, a new neuroprotective compound from Streptomyces sp. RAP78

被引：0
|
作者：
Yuta Ibusuki
Shoko Kimata
Yoichi Hayakawa
机构：
[1] Tokyo University of Science,Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences
来源：
The Journal of Antibiotics | 2022年 / 75卷
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摘要：
A neuroprotective compound (2) was isolated from the culture broth of the dutomycin (1) producer Streptomyces sp. RAP78. The molecular formula of 2 was established as C44H55NO16 by high-resolution FAB-MS. The structure was determined to be a new dutomycin derivative possessing an acetimidoyl group in place of an acetyl group by NMR spectroscopic analysis. 13-Deoxo-13-iminodutomycin (2) but not dutomycin (1) protected C6 rat glioma cells and N18-RE-105 rat primary retina-mouse neuroblastoma hybrid cells from glutamate-induced toxicity with EC50s of 0.12 µM and 0.72 µM, respectively.
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页码：40 / 43
页数：3
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