Ramucirumab after prior sorafenib in patients with advanced hepatocellular carcinoma and elevated alpha-fetoprotein: Japanese subgroup analysis of the REACH-2 trial

被引:0
|
作者
Masatoshi Kudo
Takuji Okusaka
Kenta Motomura
Izumi Ohno
Manabu Morimoto
Satoru Seo
Yoshiyuki Wada
Shinpei Sato
Tatsuya Yamashita
Masayuki Furukawa
Takeshi Aramaki
Seijin Nadano
Kazuyoshi Ohkawa
Hirofumi Fujii
Toshihiro Kudo
Junji Furuse
Hiroki Takai
Gosuke Homma
Reigetsu Yoshikawa
Andrew X. Zhu
机构
[1] Kindai University Faculty of Medicine,Department of Gastroenterology and Hepatology
[2] National Cancer Center Hospital,Graduate School of Medicine
[3] Aso Iizuka Hospital,Graduate School of Medicine
[4] National Cancer Center Hospital East,Graduate School of Medicine
[5] Kanagawa Cancer Center,undefined
[6] Kyoto University,undefined
[7] National Hospital Organization Kyushu Medical Center,undefined
[8] Kyoundo Hospital,undefined
[9] Sasaki Institute,undefined
[10] Kanazawa University,undefined
[11] National Hospital Organization Kyushu Cancer Center,undefined
[12] Shizuoka Cancer Center Hospital,undefined
[13] National Hospital Organization Shikoku Cancer Center,undefined
[14] Osaka International Cancer Institute,undefined
[15] Jichi Medical University,undefined
[16] Osaka University,undefined
[17] Kyorin University Faculty of Medicine,undefined
[18] Eli Lilly Japan K.K.,undefined
[19] Massachusetts General Hospital Cancer Center,undefined
[20] Harvard Medical School,undefined
来源
关键词
Alpha-fetoprotein; Hepatocellular carcinoma; Japanese subanalysis; Ramucirumab; VEGFR2;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
页码:627 / 639
页数:12
相关论文
共 50 条
  • [31] Alpha-fetoprotein kinetics in patients with hepatocellular carcinoma receiving ramucirumab or placebo: an analysis of the phase 3 REACH study
    Chau, Ian
    Park, Joon Oh
    Ryoo, Baek-Yeol
    Yen, Chia-Jui
    Poon, Ronnie
    Pastorelli, Davide
    Blanc, Jean-Frederic
    Kudo, Masatoshi
    Pfiffer, Tulio
    Hatano, Etsuro
    Chung, Hyun Cheol
    Kopeckova, Katerina
    Phelip, Jean-Marc
    Brandi, Giovanni
    Ohkawa, Shinichi
    Li, Chung-Pin
    Okusaka, Takuji
    Hsu, Yanzhi
    Abada, Paolo B.
    Zhu, Andrew X.
    BRITISH JOURNAL OF CANCER, 2018, 119 (01) : 19 - 26
  • [32] PATIENT-REPORTED OUTCOMES (PROS) WITH RAMUCIRUMAB VERSUS PLACEBO IN CHINESE PATIENTS WITH HEPATOCELLULAR CARCINOMA (HCC) AND ELEVATED ALPHA-FETOPROTEIN FROM THE RANDOMIZED PHASE 3 REACH-2 STUDY
    Chen, X.
    Shao, G.
    Bai, Y.
    Gu, S.
    Gu, K.
    Zhang, Q.
    Zhang, W.
    Liu, J.
    Zhou, L.
    Qin, S.
    VALUE IN HEALTH, 2022, 25 (12) : S19 - S20
  • [33] Impact of baseline hepatitis B viremia and management on outcomes in patients (Pts) with advanced hepatocellular carcinoma (HCC) and elevated alpha-fetoprotein (AFP): Outcomes from REACH-2
    Galle, Peter R.
    Kudo, Masatoshi
    Llovet, Josep M.
    Finn, Richard S.
    Karwal, Mark
    Pezet, Denis
    Kim, Tae-You
    Yang, Tsai-Sheng
    Zagonel, Vittorina
    Tomasek, Jiri
    Phelip, Jean Marc
    Touchefeu, Yann
    Koh, Su-Jin
    Stirnimann, Guido
    Wang, Chunxiao
    Ogburn, Kenyon
    Abada, Paolo
    Widau, Ryan C.
    Zhu, Andrew X.
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (04)
  • [34] SERIAL ALPHA-FETOPROTEIN ASSESSMENT AND SURVIVAL IN PATIENTS WITH ADVANCED HEPATOCELLULAR CARCINOMA RECEIVING SORAFENIB
    Personeni, Nicola
    Bozzarelli, Silvia
    Giordano, Laura
    Rimassa, Lorenza
    Pressiani, Tiziana
    Tronconi, Maria Chiara
    Sclafani, Francesco
    Carnaghi, Carlo
    Santoro, Armando
    ANNALS OF ONCOLOGY, 2009, 20
  • [35] Early decrease of alpha-fetoprotein predicts sorafenib efficacy in patients with advanced hepatocellular carcinoma
    Kuzuya, Teiji
    Katano, Yoshiaki
    Ishigami, Masatoshi
    Hayashi, Kazuhiko
    Honda, Takashi
    Goto, Hidemi
    HEPATOLOGY, 2012, 56 : 455A - 455A
  • [36] Ramucirumab in patients with advanced hepatocellular carcinoma (HCC) and elevated alpha fetoprotein (AFP): An exposure-response analysis
    Llovet, J.
    Kudo, M.
    Kang, Y-K.
    Yen, C-J.
    Finn, R. S.
    Galle, P. R.
    Assenat, E.
    Motomura, K.
    Okusaka, T.
    Berg, T.
    Hsu, C-H.
    Ikeda, M.
    Hsu, Y.
    Liang, K.
    Widau, R.
    Schelman, W.
    O'Brien, L.
    Gao, L.
    Zhu, A. X.
    ANNALS OF ONCOLOGY, 2019, 30 : 293 - +
  • [37] Early alpha-fetoprotein response predicts survival in patients with advanced hepatocellular carcinoma treated with sorafenib
    Lee, Sangheun
    Kim, Beom Kyung
    Kim, Seung Up
    Park, Jun Yong
    Kim, Do Young
    Ahn, Sang Hoon
    Han, Kwang-Hyub
    JOURNAL OF HEPATOCELLULAR CARCINOMA, 2015, 2 : 39 - +
  • [38] Efficacy and safety of ramucirumab (RAM) in Asian and non-Asian patients with advanced hepatocellular carcinoma (HCC) and elevated alpha-fetoprotein (AFP): Subgroup analysis from two randomized studies
    Kang, Y-K.
    Kudo, M.
    Lim, H-Y.
    Hsu, C-H.
    Vogel, A.
    Brandi, G.
    Cheng, R.
    Carton, I.
    Abada, P.
    Hsu, Y.
    Zhu, A.
    Yen, C-J.
    ANNALS OF ONCOLOGY, 2018, 29 : 46 - 46
  • [39] REACH-2: A randomized, double-blind, placebo-controlled phase 3 study of ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma (HCC) and elevated baseline alpha-fetoprotein (AFP) following first-line sorafenib
    Gerken, G.
    Zhu, A.
    Kang, Y-K
    Yen, C-J
    Finn, R.
    Galle, P.
    Llovet, J.
    Assenat, E.
    Brandi, G.
    Lim, H. Y.
    Pracht, M.
    Rau, K-M
    Merle, P.
    Motomura, K.
    Ohno, I
    Daniele, B.
    Shin, D. B.
    Abada, P. B.
    Hsu, Y.
    Kudo, M.
    ONCOLOGY RESEARCH AND TREATMENT, 2018, 41 : 253 - 254
  • [40] A randomized, double-blind, placebo-controlled Phase III study of ramucirumab versus placebo as second-line treatment in patients with hepatocellular carcinoma and elevated baseline alpha-fetoprotein following first-line sorafenib (REACH-2)
    Andrew, Zhu
    Peter, Galle
    Masatoshi, Kudo
    Richard, Finn
    Ling, Yang
    Paolo, Abada
    Josep, Llovet
    ANNALS OF ONCOLOGY, 2016, 27 : 83 - 83