Merging structural biology with chemical biology: Structural Chemistry at Eskitis

被引：0

作者：

Andreas Hofmann

Conan K. Wang

Asiah Osman

David Camp

机构：

[1] Structural Chemistry Program,

[2] Eskitis Institute for Cell and Molecular Therapies,undefined

[3] Griffith University,undefined

[4] Queensland Compound Library,undefined

[5] Eskitis Institute for Cell and Molecular Therapies,undefined

[6] Griffith University,undefined

来源：

Structural Chemistry | 2010年 / 21卷

关键词：

Molecular mechanisms; Protein crystallography; Protein structure–function; Rational drug design;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This review introduces the Structural Chemistry Program at Griffith University’s Eskitis Institute, and provides a brief overview over its current and future research portfolio. Capitalising on the co-location with the Queensland Compound Library (QCL), Australia’s only small molecule repository, our laboratory investigates the structure and function of proteins with the aim of learning about their molecular mechanisms. Consequently, these studies also feed into drug discovery and design. The thematic focus of our Program is on proteins involved in infection, inflammation and neurological diseases, and this review highlights a few of our recent research efforts in this area.

引用

页码：1117 / 1129

页数：12

共 50 条

[21] Advances in Protein Chemistry and Structural Biology PREFACE
Donev, Rossen
PEPTIDE AND PROTEIN VACCINES, 2015, 99 : XI - XIII
[22] Structural biology and chemistry of protein arginine methyltransferases
Schapira, Matthieu
de Freitas, Renato Ferreira
MEDCHEMCOMM, 2014, 5 (12) : 1779 - 1788
[23] Advances in Protein Chemistry and Structural Biology PREFACE
Donev, Rossen
PROTEIN AND PEPTIDE NANOPARTICLES FOR DRUG DELIVERY, 2015, 98 : XIII - XV
[24] STRUCTURAL CRYSTALLOGRAPHY IN CHEMISTRY AND BIOLOGY - GLUSKER,JP
ABOLA, JE
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (08) : 2521 - 2521
[25] The use of stereoscopic visualization in chemistry and structural biology
Husak, Michal
Stereoscopic Displays and Virtual Reality Systems XIII, 2006, 6055 : 5501 - 5501
[26] Orthogonal multipolar interactions in structural chemistry and biology
Paulini, R
Müller, K
Diederich, F
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (12) : 1788 - 1805
[27] Advances in Protein Chemistry and Structural Biology PREFACE
Christov, Christo Z.
INSIGHTS INTO ENZYME MECHANISMS AND FUNCTIONS FROM EXPERIMENTAL AND COMPUTATIONAL METHODS, 2016, 105 : IX - IX
[28] Advances in Protein Chemistry and Structural Biology PREFACE
Donev, Rossen
CHROMATIN PROTEINS AND TRANSCRIPTION FACTORS AS THERAPEUTIC TARGETS, 2017, 107 : XIII - XVI
[29] Merging Chemistry and Biology in Emerging Countries
Suzuki, Takayoshi
Arai, Midori A.
Nakashima, Mitsue
Uesugi, Motonari
CHEMISTRY & BIOLOGY, 2013, 20 (04): : 461 - 465
[30] Structural biology
Nature Reviews Drug Discovery, 2008, 7 (9) : 783 - 783

← 1 2 3 4 5 →