Current concepts of the intestinal microbiota and the pathogenesis of infection

被引：75
|
作者：
Wardwell L.H. [1 ,4 ]
Huttenhower C. [3 ]
Garrett W.S. [1 ,2 ,4 ,5 ]
机构：
[1] Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, 665 Huntington Avenue
[2] Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, 665 Huntington Avenue
[3] Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, 655 Huntington Avenue
[4] Harvard Medical School, Boston, MA
[5] Dana Farber Cancer Institute, Boston, MA
来源：
Current Infectious Disease Reports | 2011年 / 13卷 / 1期
关键词：
Bacteria; Commensal; Gastrointestinal; Gut; Infection; Infectious disease; Intestine; Microbial community; Microbiota;
D O I：
10.1007/s11908-010-0147-7
中图分类号：
学科分类号：
摘要：
The human gastrointestinal tract is populated by a vast and diverse community of microbes. This gut microbiota participates in host metabolism, protects from invading microbes, and facilitates immune system development and function. In this review, we consider the contributions of intestinal microbes to the pathogenesis of infectious diseases. Key concepts of colonization resistance, host-commensal microbe interaction in immunity, antibiotics and gut bacterial communities, viral-gut bacterial interactions, and evolving methods for studying commensal microbes are explored. © 2010 Springer Science+Business Media, LLC.
引用
收藏
页码：28 / 34
页数：6
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