Three pairs of monozygotic twins with fibrodysplasia ossificans progressiva: The role of environment in the progression of heterotopic ossification

被引：27
|
作者：
Hebela N. [1 ,4 ]
Shore E.M. [1 ,2 ,4 ]
Kaplan F.S. [1 ,3 ,4 ,5 ]
机构：
[1] Department of Orthopaedic Surgery, University of Pennsylvania, School of Medicine, Philadelphia, PA
[2] Department of Genetics, University of Pennsylvania, School of Medicine, Philadelphia, PA
[3] Department of Medicine, University of Pennsylvania, School of Medicine, Philadelphia, PA
[4] Center for Research in FOP and Related Disorders, University of Pennsylvania, School of Medicine, Philadelphia, PA
[5] University of Pennsylvania, School of Medicine, Department of Orthopaedic Surgery, Philadelphia, PA 19104, Silverstein Two
来源：
Clinical Reviews in Bone and Mineral Metabolism | 2005年 / 3卷 / 3-4期
关键词：
Fibrodysplasia ossificans progressiva (FOP); Heterotopic ossification; Twins;
D O I：
10.1385/BMM:3:3-4:205
中图分类号：
学科分类号：
摘要：
Genetic and environmental factors affect the phenotype of fibrodysplasia ossificans progressiva (FOP) but their relative effects are unknown. We studied three pairs of monozygotic twins with FOP and found that, within each pair, congenital toe malformations were identical. However, postnatal heterotopic ossification varied greatly depending on life history and environmental exposure. This study shows that genetic determinants strongly influence disease phenotype during prenatal development and that environmental factors strongly influence postnatal progression of the disease. © Copyright 2005 by Humana Press Inc. All rights of any nature whatsoever reserved.
引用
收藏
页码：205 / 208
页数：3
相关论文
共 50 条
  • [31] Alk2 Regulates Early Chondrogenic Fate in Fibrodysplasia Ossificans Progressiva Heterotopic Endochondral Ossification
    Culbert, Andria L.
    Chakkalakal, Salin A.
    Theosmy, Edwin G.
    Brennan, Tracy A.
    Kaplan, Frederick S.
    Shore, Eileen M.
    STEM CELLS, 2014, 32 (05) : 1289 - 1300
  • [32] HETEROTOPIC OSSIFICATION IN PALOVAROTENE-TREATED AND UNTREATED INDIVIDUALS WITH FIBRODYSPLASIA OSSIFICANS PROGRESSIVA: MATCHED AND WEIGHTED ANALYSES
    Al Mukaddam, M.
    Baujat, G.
    Cheung, A. M.
    De Cunto, C.
    Hsiao, E. C.
    Keen, R.
    Marden, J.
    Signorovitch, J.
    Boing, E.
    Marino, R.
    Strahs, A.
    Pignolo, R. J.
    VALUE IN HEALTH, 2023, 26 (06) : S20 - S20
  • [33] RELATIONSHIPS BETWEEN HETEROTOPIC OSSIFICATION VOLUME AND FUNCTIONAL AND QUALITY OF LIFE ENDPOINTS IN FIBRODYSPLASIA OSSIFICANS PROGRESSIVA (FOP)
    Verburg-Baltussen, L.
    Dunnewind, N.
    Kroep, S.
    Hout, B., V
    Boing, E.
    Keen, R.
    VALUE IN HEALTH, 2023, 26 (06) : S28 - S29
  • [34] An unusual case of adult onset progressive heterotopic ossification suggesting a variant form of fibrodysplasia ossificans progressiva
    Jayasundara, J. A. S. B.
    Punchihewa, G. L.
    de Alwis, D. S.
    SINGAPORE MEDICAL JOURNAL, 2012, 53 (04) : E83 - E86
  • [35] The Relationship of Flare-Ups and Heterotopic Ossification in Patients with Fibrodysplasia Ossificans Progressiva: LUMINA-1 Data
    Keen, Richard
    McGinniss, Jennifer
    Forleo-Neto, Eduardo
    Mellis, Scott
    Dahir, Kathryn
    Di Rocco, Maja
    Szczepanek, Magorzata
    Bachiller-Corral, Javier
    Cheung, Angela
    Al Mukaddam, Mona
    Gu, Jing
    Economides, Aris
    Srinivasan, Dushyanth
    Trotter, Dinko Gonzalez
    Kaplan, Frederick
    Eekhoff, Elisabeth
    Pignolo, Robert
    JOURNAL OF BONE AND MINERAL RESEARCH, 2023, 38 : 71 - 71
  • [36] Clearance of Senescent Cells From Injured Muscle Abrogates Heterotopic Ossification in Mouse Models of Fibrodysplasia Ossificans Progressiva
    Wang, Haitao
    Zhang, Qiang
    Kaplan, Frederick S.
    Pignolo, Robert J.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2022, 37 (01) : 95 - 107
  • [37] Palovarotene (Sohonos), a synthetic retinoid for reducing new heterotopic ossification in fibrodysplasia ossificans progressiva: history, present, and future
    Hsiao, Edward C.
    Pacifici, Maurizio
    JBMR PLUS, 2024, 9 (01)
  • [38] [18F]NaF PET/CT scan as an early marker of heterotopic ossification in fibrodysplasia ossificans progressiva
    Eekhoff, E. Marelise W.
    Botman, Esmee
    Netelenbos, J. Coen
    de Graaf, Pim
    Bravenboer, Nathalie
    Micha, Dimitra
    Pals, Gerard
    de Vries, Teun J.
    Schoenmaker, Ton
    Hoebink, Max
    Lammertsma, Adriaan A.
    Raijmakers, Pieter G. H. M.
    BONE, 2018, 109 : 143 - 146
  • [39] RELATING HETEROTOPIC OSSIFICATION VOLUME TO JOINT FUNCTION AND QUALITY OF LIFE: A SIMULATION STUDY IN FIBRODYSPLASIA OSSIFICANS PROGRESSIVA (FOP)
    Verburg-Baltussen, L.
    Gittfried, A.
    Kroep, S.
    Hout, B., V
    Boing, E.
    Keen, R.
    VALUE IN HEALTH, 2023, 26 (06) : S288 - S288
  • [40] New Heterotopic Ossification Lesions in Patients with Fibrodysplasia Ossificans Progressiva Measured by PET/CT vs CT Only
    Trotter, Dinko Gonzalez
    McGinniss, Jennifer
    Economides, Aris
    Mohammadi, Kusha
    Rankin, Andrew
    Musser, Bret
    Mellis, Scott
    Forleo-Neto, Eduardo
    Herman, Gary
    JOURNAL OF BONE AND MINERAL RESEARCH, 2023, 38 : 371 - 372
12345