Intraepithelial lymphocytes: To serve and protect

被引：65
|
作者：
Sheridan B.S. [1 ]
Lefrançois L. [1 ]
机构：
[1] Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030
来源：
Current Gastroenterology Reports | 2010年 / 12卷 / 6期
基金：
美国国家卫生研究院;
关键词：
γδ T cell; CD8αβ T cell; Immunologic memory; Intestinal homeostasis; Intraepithelial lymphocyte; Microbial surveillance; Mucosal immunology; T-cell migration;
D O I：
10.1007/s11894-010-0148-6
中图分类号：
学科分类号：
摘要：
The mucosal immune system is constantly exposed to a wide range of commensal and potentially pathogenic microbial species. Chronic exposure to foreign organisms makes generation of an appropriate immune response critical in maintaining a balance between elimination of harmful pathogens, peaceful coexistence with commensals, and prevention of autoimmunity. Intestinal intraepithelial lymphocytes provide a first line of defense at this extensive barrier with the outside world, and as such, understanding their role in immunity is critical. © 2010 Springer Science+Business Media, LLC.
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页码：513 / 521
页数：8
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