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- [4] To protect and serveJOURNAL OF THE ROYAL SOCIETY FOR THE PROMOTION OF HEALTH, 2004, 124 (03): : 107 - 107Lonsdale, JStewart, W
Intraepithelial lymphocytes: To serve and protect
被引：65
|作者：
Sheridan B.S.
[1
]
Lefrançois L.
[1
]
机构：
[1] Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030
基金：
美国国家卫生研究院;
关键词：
γδ T cell;
CD8αβ T cell;
Immunologic memory;
Intestinal homeostasis;
Intraepithelial lymphocyte;
Microbial surveillance;
Mucosal immunology;
T-cell migration;
D O I：
10.1007/s11894-010-0148-6
中图分类号：
学科分类号：
摘要：
The mucosal immune system is constantly exposed to a wide range of commensal and potentially pathogenic microbial species. Chronic exposure to foreign organisms makes generation of an appropriate immune response critical in maintaining a balance between elimination of harmful pathogens, peaceful coexistence with commensals, and prevention of autoimmunity. Intestinal intraepithelial lymphocytes provide a first line of defense at this extensive barrier with the outside world, and as such, understanding their role in immunity is critical. © 2010 Springer Science+Business Media, LLC.
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页码：513 / 521
页数：8
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