Epigenetics, vitamin supplements and cellular reprogramming

被引：0
|
作者：
Martin F Pera
机构：
[1] University of Melbourne,Martin F. Pera is at the Department of Anatomy and Neuroscience
[2] the Walter and Eliza Hall Institute of Medical Research,undefined
[3] and the Florey Neuroscience and Mental Health Institute,undefined
[4] Melbourne,undefined
[5] Victoria,undefined
[6] Australia.,undefined
来源：
Nature Genetics | 2013年 / 45卷
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摘要：
The simple addition of vitamin C to cell culture medium can induce extensive remodeling of the cellular epigenome and facilitates reprogramming of somatic cells to pluripotency. A new study shows that the activity of the enzyme TET1 can inhibit or enhance reprogramming efficiency, dependent on the presence or absence of vitamin C.
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页码：1412 / 1413
页数：1
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