Epigenetics, vitamin supplements and cellular reprogramming

被引：9
|
作者：
Pera, Martin F. [1 ,2 ]
机构：
[1] Univ Melbourne, Dept Anat & Neurosci, Walter & Eliza Hall Inst Med Res, Melbourne, Vic, Australia
[2] Florey Neurosci & Mental Hlth Inst, Melbourne, Vic, Australia
来源：
NATURE GENETICS | 2013年 / 45卷 / 12期
关键词：
STEM-CELLS; TET1;
D O I：
10.1038/ng.2834
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The simple addition of vitamin C to cell culture medium can induce extensive remodeling of the cellular epigenome and facilitates reprogramming of somatic cells to pluripotency. A new study shows that the activity of the enzyme TET1 can inhibit or enhance reprogramming efficiency, dependent on the presence or absence of vitamin C.
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页码：1412 / 1413
页数：2
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