Combined Orofacial Aspergillosis and Mucormycosis: Fatal Complication of a Recurrent Paediatric Glioma—Case Report and Review of Literature

被引:0
|
作者
Maddalena Chermetz
Margherita Gobbo
Katia Rupel
Giulia Ottaviani
Giancarlo Tirelli
Rossana Bussani
Roberto Luzzati
Roberto Di Lenarda
Matteo Biasotto
机构
[1] University of Trieste,Division of Oral Medicine, Dental Science Department
[2] Cattinara Hospital,Department of Otorhinolaryngology, Head and Neck Surgery
[3] Cattinara Hospital,UCO Pathological Anatomy and Histopathology Unit
[4] University Hospital,Infectious Diseases Unit
来源
Mycopathologia | 2016年 / 181卷
关键词
Mucormycosis; Aspergillosis; Invasive fungal infection; Early diagnosis;
D O I
暂无
中图分类号
学科分类号
摘要
Mucormycosis and aspergillosis are two opportunistic fungal infections, which can evolve into life-threatening complications. They generally affect patients with relevant risk factors such as immunocompromisation or long-term use of antibiotics or corticosteroids. Treatment usually combines medical and surgical approaches, often including extended necrosectomies, although the prognosis of generalized fungal infections is very poor. In this paper, we present the case of a 17-year-old girl affected by combined aspergillosis and mucormycosis, following treatment of a recurrent glioma. The patient was hospitalized for a suspected cellulitis of the right hemi-face, involving frontal maxillary area and the upper airways and was immediately put on intravenous antibiotic therapies; after performing nasal septum and maxillary biopsies, concomitant mucormycosis and aspergillosis were diagnosed and antimycotic therapy with liposomal B-amphotericin was administered. After evaluation by the oral surgeon and otolaryngologist, surgical cranio-facial necrosectomy was suggested, but refused by the parents of the patient. The girl died only few days later, due to a respiratory arrest. Awareness of this pathology with prompt diagnosis and early treatment may improve the outcome of these infections and reduce the mortality.
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页码:723 / 733
页数:10
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