Interval Mapping Using Nonparametric Accelerated Failure Time Cure Model

被引:0
|
作者
Devrim Bilgili
Nader Ebrahimi
机构
[1] University of North Florida,Department of Mathematics and Statistics
[2] Northern Illinois University,Department of Mathematical Sciences, Statistics Divison
来源
关键词
Survival Function; Interval Mapping; AFT Cure Model; LOD score; EM; Imputation;
D O I
10.2991/jsta.2013.12.4.6
中图分类号
学科分类号
摘要
Many important problems in evolutionary biology begin with observations of phenotypic variation. Suppose time to an event-data are used to map quantitative trait loci (QTL) and underlying population is a mixture of susceptible and non-susceptible subjects. If the cured subjects are ignored we may fail to detect the responsible genetic factors or find false significant locations. In this article, we propose a nonparametric accelerated failure time cure model which takes cured subjects as well to model time to an event.
引用
收藏
页码:392 / 402
页数:10
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