Interval Mapping Using Nonparametric Accelerated Failure Time Cure Model

被引：0

作者：

Devrim Bilgili

Nader Ebrahimi

机构：

[1] University of North Florida,Department of Mathematics and Statistics

[2] Northern Illinois University,Department of Mathematical Sciences, Statistics Divison

来源：

Journal of Statistical Theory and Applications | 2013年 / 12卷 / 4期

关键词：

Survival Function; Interval Mapping; AFT Cure Model; LOD score; EM; Imputation;

D O I：

10.2991/jsta.2013.12.4.6

中图分类号：

学科分类号：

摘要：

Many important problems in evolutionary biology begin with observations of phenotypic variation. Suppose time to an event-data are used to map quantitative trait loci (QTL) and underlying population is a mixture of susceptible and non-susceptible subjects. If the cured subjects are ignored we may fail to detect the responsible genetic factors or find false significant locations. In this article, we propose a nonparametric accelerated failure time cure model which takes cured subjects as well to model time to an event.

引用

页码：392 / 402

页数：10

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