Synthesis and cytotoxic activity of trinitromethyl derivatives of 1,3,5-triazine

被引：0
|
作者：
Bakharev V.V. [1 ]
Gidaspov A.A. [1 ]
Yakunina N.G. [2 ]
Bulychev Yu.N. [2 ]
机构：
[1] Samara State Technical University, Samara
[2] Science Research Institute of Experimental Tumor Diagnosis and Treatment, N. N. Blokhin Russian Oncological Scientific Center, Russian Academy of Medical Sciences, Moscow
来源：
Pharmaceutical Chemistry Journal | 2008年 / 42卷 / 5期
关键词：
Cytotoxic Activity; Triazine; Human Tumor Cell Line; Compound VIII; Cyanuric Chloride;
D O I：
10.1007/s11094-008-0101-2
中图分类号：
学科分类号：
摘要：
New trinitromethyl derivatives of 1,3,5-triazine were synthesized with different substituents in positions 2 and 4. Data on the in vitro cytotoxic activity of the resulting compounds were obtained using a panel of 60 human tumor cell lines. The most active compounds were the 2,4-diamino-and 2-dimethylamino-4-azido derivatives. In terms of the general level of cytotoxicity, compounds of this series were more active than previously studied polynitromethyl derivatives of 1,3,5-triazine. © 2008 Springer Science+Business Media, Inc.
引用
收藏
页码：241 / 244
页数：3
相关论文
共 50 条
  • [1] Crystal structures of some trinitromethyl derivatives of 1,3,5-triazine
    Z. G. Aliev
    A. V. Shastin
    S. M. Aldoshin
    [J]. Journal of Structural Chemistry, 2015, 56 : 1160 - 1165
  • [2] Crystal structures of some trinitromethyl derivatives of 1,3,5-triazine
    Aliev, Z. G.
    Shastin, A. V.
    Aldoshin, S. M.
    [J]. JOURNAL OF STRUCTURAL CHEMISTRY, 2016, 56 (06) : 1160 - 1165
  • [3] Synthesis and antivirus activity of 1,3,5-triazine derivatives
    Wang, QM
    Liu, G
    Shao, RL
    Huang, RQ
    [J]. HETEROATOM CHEMISTRY, 2003, 14 (06) : 542 - 545
  • [4] Synthesis of some 1,3,5-triazine derivatives
    Azarifar, D
    Forghaniha, A
    [J]. HETEROCYCLES, 2006, 68 (04) : 807 - 810
  • [5] SYNTHESIS OF 2,4,6-TRIS(TRINITROMETHYL)-1,3,5-TRIAZINE
    SHASTIN, AV
    GODOVIKOVA, TI
    GOLOVA, SP
    KUZMIN, VS
    KHMELNITSKII, LI
    KORSUNSKII, BL
    [J]. MENDELEEV COMMUNICATIONS, 1995, (01) : 17 - 18
  • [6] Synthesis and Cytotoxic Activity of Hexahydro-1,3,5-triazine Derivatives through Ring Condensation
    Bae, Song Mi
    Kang, Sung Young
    Song, Ju Hyun
    [J]. BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2021, 42 (06) : 840 - 846
  • [7] SYNTHESIS OF NEW 1,3,5-THIADIAZINE AND 1,3,5-TRIAZINE DERIVATIVES AND THEIR ANTIMICROBIAL ACTIVITY
    CHANDE, MS
    DRAVID, RN
    SHETGIRI, NP
    [J]. PROCEEDINGS OF THE INDIAN ACADEMY OF SCIENCES-CHEMICAL SCIENCES, 1988, 100 (01): : 53 - 58
  • [8] Biguanide-Based Synthesis of 1,3,5-Triazine Derivatives with Anticancer Activity and 1,3,5-Triazine Incorporated Calcium Citrate Nanoparticles
    Chalermnon, Monnaya
    Cherdchom, Sarocha
    Sereemaspun, Amornpun
    Rojanathanes, Rojrit
    Khotavivattana, Tanatorn
    [J]. MOLECULES, 2021, 26 (04):
  • [9] PHOSPHORYLATED 1,3,5-TRIAZINE DERIVATIVES
    SHOKOL, VA
    KOZHUSHKO, BN
    KOLESNIKOV, AM
    [J]. ZHURNAL OBSHCHEI KHIMII, 1975, 45 (09): : 2093 - 2094
  • [10] Thermal decomposition of 2,4-diazido-6-trinitromethyl-1,3,5-triazine, 2,4-dimethoxy-6-trinitromethyl-1,3,5-triazine, and 2,4-diazido-6-methoxy-1,3,5-triazine
    V. V. Nedel’ko
    V. V. Zakharov
    B. L. Korsounskii
    T. S. Larikova
    N. V. Chukanov
    A. V. Shastin
    [J]. Russian Journal of Physical Chemistry B, 2015, 9 : 885 - 889
12345