Involvement of TRPM2 and TRPM8 in temperature-dependent masking behavior

被引:0
|
作者
Wataru Ota
Yusuke Nakane
Makiko Kashio
Yoshiro Suzuki
Kazuhiro Nakamura
Yasuo Mori
Makoto Tominaga
Takashi Yoshimura
机构
[1] Nagoya University,Institute of Transformative Bio
[2] Furo-cho,Molecules (WPI
[3] Chikusa-ku,ITbM)
[4] Graduate School of Bioagricultural Sciences,Laboratory of Animal Integrative Physiology
[5] Nagoya University,Avian Bioscience Research Center
[6] Furo-cho,Department of Physiology
[7] Chikusa-ku,Division of Cell Signaling
[8] Graduate School of Bioagricultural Sciences,Thermal Biology Group
[9] Nagoya University,Department of Integrative Physiology
[10] Furo-cho,Department of Synthetic Chemistry and Biological Chemistry
[11] Chikusa-ku,Division of Seasonal Biology
[12] Aichi Medical University,undefined
[13] National Institute for Physiological Sciences,undefined
[14] National Institutes of Natural Sciences,undefined
[15] Exploratory Research Center on Life and Living Systems,undefined
[16] National Institutes of Natural Sciences,undefined
[17] Nagoya University Graduate School of Medicine,undefined
[18] Graduate School of Engineering,undefined
[19] Kyoto University,undefined
[20] Nishikyo-ku,undefined
[21] National Institute for Basic Biology,undefined
[22] National Institutes of Natural Sciences,undefined
来源
关键词
D O I
暂无
中图分类号
学科分类号
摘要
Masking is a direct behavioral response to environmental changes and plays an important role in the temporal distribution of activity. However, the mechanisms responsible for masking remain unclear. Here we identify thermosensors and a possible neural circuit regulating temperature-dependent masking behavior in mice. Analysis of mice lacking thermosensitive transient receptor potential (TRP) channels (Trpv1/3/4 and Trpm2/8) reveals that temperature-dependent masking is impaired in Trpm2- and Trpm8-null mice. Several brain regions are activated during temperature-dependent masking, including the preoptic area (POA), known as the thermoregulatory center, the suprachiasmatic nucleus (SCN), which is the primary circadian pacemaker, the paraventricular nucleus of the thalamus (PVT), and the nucleus accumbens (NAc). The POA, SCN, PVT are interconnected, and the PVT sends dense projections to the NAc, a key brain region involved in wheel-running activity. Partial chemical lesion of the PVT attenuates masking, suggesting the involvement of the PVT in temperature-dependent masking behavior.
引用
收藏
相关论文
共 50 条
  • [21] Trigeminal Neuralgia TRPM8 Mutation
    Gualdani, Roberta
    Yuan, Jun-Hui
    Effraim, Philip R.
    Di Stefano, Giulia
    Truini, Andrea
    Cruccu, Giorgio
    Dib-Hajj, Sulayman D.
    Gailly, Philippe
    Waxman, Stephen G.
    NEUROLOGY-GENETICS, 2021, 7 (01)
  • [22] TRPM8的研究现状
    关荣华
    林小娥
    科学技术创新, 2017, (26) : 4 - 5
  • [23] TRPM8 is an Ionotropic Testosterone Receptor
    Asuthkar, Swapna
    Demirkhanyan, Lusine
    Sun, Xiaohui
    Elustondo, Pia
    Krishnan, Vivek
    Baskaran, Padmamalini
    Velpula, Kiran Kumar
    Thyagarajan, Baskaran
    Pavlov, Evgeny
    Zakharian, Eleonora
    BIOPHYSICAL JOURNAL, 2015, 108 (02) : 38A - 38A
  • [24] Characterisation of TRPM8 as a pharmacophore receptor
    Boedding, Matthias
    Wissenbach, Ulrich
    Flockerzi, Veit
    CELL CALCIUM, 2007, 42 (06) : 618 - 628
  • [25] TRPM8 Biology and Medicinal Chemistry
    DeFalco, Jeff
    Duncton, Matthew A. J.
    Emerling, Daniel
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2011, 11 (17) : 2237 - 2252
  • [26] Molecular mechanism of desensitization of TRPM8
    Hosokawa, Hiroshi
    Abe, Junji
    Yamanaka, Keiji
    Matsumura, Kiyoshi
    Kobayashi, Shigeo
    NEUROSCIENCE RESEARCH, 2006, 55 : S140 - S140
  • [27] TRPM8 and prostate: a cold case?
    Noyer, Lucile
    Grolez, Guillaume P.
    Prevarskaya, Natalia
    Gkika, Dimitra
    Lemonnier, Loic
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 2018, 470 (10): : 1419 - 1429
  • [28] TRPM8 influences bladder filling
    Peter Sidaway
    Nature Reviews Urology, 2015, 12 (9) : 476 - 476
  • [29] Regulation of TRPM8 channel activity
    Yudin, Yevgen
    Rohacs, Tibor
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2012, 353 (1-2) : 68 - 74
  • [30] Cooling the Itch via TRPM8
    Liu, Boyi
    Jordt, Sven-Eric
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2018, 138 (06) : 1254 - 1256