MDM2 in breast cancer

被引：15
|
作者：
Masakazu Toi
Shigehira Saji
Akio Suzuki
Yutaka Yamamoto
Takeshi Tominaga
机构：
[1] Tokyo Metropolitan Komagome Hospital,Department of Surgery
来源：
Breast Cancer | 1997年 / 4卷 / 4期
关键词：
MDM2; Breast cancer; Drug resistance;
D O I：
10.1007/BF02966519
中图分类号：
学科分类号：
摘要：
TheMDM2 protein, an oncogene product, is known to act by suppressing p53 function. Although gene amplification ofMDM2 was frequently detected in human sarcomas, it was uncommon in the majority of epithelial tumors including breast cancer. However, recent reports have demonstrated that its translational activity is enhanced in a variety of carcinomas. In this report, we summarized the implications ofMDM2 overexpression in human breast cancer from the literature as well as our preliminary results.
引用
收藏
页码：264 / 268
页数：4
相关论文
共 50 条
  • [21] Overexpression of MDM2 oncoprotein correlates with possession of estrogen receptor alpha and lack of MDM2 mRNA splice variants in human breast cancer
    Hori, M
    Shimazaki, J
    Inagawa, S
    Itabashi, M
    Hori, M
    BREAST CANCER RESEARCH AND TREATMENT, 2002, 71 (01) : 77 - 83
  • [22] Overexpression of MDM2 oncoprotein correlates with possession of estrogen receptor alpha and lack of MDM2 mRNA splice variants in human breast cancer
    Hori, M
    Yokose, T
    Itabashi, M
    MODERN PATHOLOGY, 2002, 15 (01) : 38A - 38A
  • [23] MDM2 enhances the function of estrogen receptor α in human breast cancer cells
    Saji, S
    Okumura, N
    Eguchi, H
    Nakashima, S
    Suzuki, A
    Toi, M
    Nozawa, Y
    Saji, S
    Hayashi, S
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 281 (01) : 259 - 265
  • [24] MDM2 regulates estrogen receptor α and estrogen responsiveness in breast cancer cells
    Kim, Kyounghyun
    Burghardt, Robert
    Barhoumi, Rola
    Lee, Syng-ook
    Liu, Xinyi
    Safe, Stephen
    JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2011, 46 (02) : 67 - 79
  • [25] The Functional Roles of the MDM2 Splice Variants P2-MDM2-10 and MDM2-Δ5 in Breast Cancer Cells
    Huun, Johanna
    Gansmo, Liv B.
    Mannsaker, Bard
    Iversen, Gjertrud T.
    Sommerfelt-Pettersen, Jan
    Ovrebo, Jan Inge
    Lonning, Per E.
    Knappskog, Stian
    TRANSLATIONAL ONCOLOGY, 2017, 10 (05): : 806 - 817
  • [26] Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival
    Tao Liu
    Hailong Zhang
    Jing Xiong
    Sha Yi
    Lubing Gu
    Muxiang Zhou
    Molecular Cancer, 14
  • [27] Inhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival
    Liu, Tao
    Zhang, Hailong
    Xiong, Jing
    Yi, Sha
    Gu, Lubing
    Zhou, Muxiang
    MOLECULAR CANCER, 2015, 14
  • [28] MDM2 splice variants in oral cancer
    Sam, K. K.
    Ng, K. L. P.
    Ismail, S. M.
    Zain, R. Binti
    Tay, K. K.
    Cheong, S. C.
    Chong, Chan Eng
    Lim, Peng
    Teo, Soo-Hwang
    ORAL ONCOLOGY, 2011, 47 : S47 - S47
  • [29] The association between p53, MDM2, and MDM2 isoform C protein expression and survival in a multiethnic population of breast cancer patients
    Loo, Lenora W.
    Hernandez, Brenda Y.
    Shvetsov, Yurii
    Okoro, Danielle
    Gao, Chong
    Bargonetti, Jill
    CANCER RESEARCH, 2017, 77
  • [30] MDM2 as a cancer therapeutic target - Editorial
    Zhang, RW
    CURRENT CANCER DRUG TARGETS, 2005, 5 (01) : 1 - 2
12345