Aquaporin-4 expression during development of the cerebellum

被引：14
|
作者：
Nico B. [1 ,4 ]
Ribatti D. [1 ]
Frigeri A. [2 ]
Nicchia G.P. [2 ]
Corsi P. [3 ]
Svelto M. [2 ]
Roncali L. [1 ]
机构：
[1] Department of Human Anatomy and Histology, University of Bari Medical School, Bari
[2] Department of General and Environmental Physiology, University of Bari Medical School, Bari
[3] Department of Physiology and Pharmacology, University of Bari Medical School, Bari
[4] Department of Human Anatomy and Histology, Policlinico, I-70124 Bari, Piazza Giulio Cesare
来源：
The Cerebellum | 2002年 / 1卷 / 3期
关键词：
Aquaporin-4; Blood-brain barrier; Cerebellum; Development; Water channel;
D O I：
10.1080/14734220260418439
中图分类号：
学科分类号：
摘要：
Aquaporins (AQPs) are small integral membrane proteins that provide a major pathway for water transport in many epithelial and endothelial cell types of several tissues. Aquaporin-4 (AQP4) is prevalently expressed in the brain and here we summarize data from our findings and from other literature concerning AQP4 expression in the cerebellum and the relationships between its expression and blood-brain barrier differentiation and integrity. The role of AQP4 in blood-brain barrier pathological conditions associated with an increased vascular permeability is also discussed. Overall, the data clearly indicate a close relationship between blood-brain barrier functioning and the control of water flux by astroglial cells and the crucial role played by AQP4 in this setting. © 2002 Martin Dunitz Ltd.
引用
收藏
页码：207 / 212
页数：5
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