Proto-genes and de novo gene birth

被引：0
|
作者：
Anne-Ruxandra Carvunis
Thomas Rolland
Ilan Wapinski
Michael A. Calderwood
Muhammed A. Yildirim
Nicolas Simonis
Benoit Charloteaux
César A. Hidalgo
Justin Barbette
Balaji Santhanam
Gloria A. Brar
Jonathan S. Weissman
Aviv Regev
Nicolas Thierry-Mieg
Michael E. Cusick
Marc Vidal
机构：
[1] Dana-Farber Cancer Institute,Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology
[2] Harvard Medical School,Department of Genetics
[3] UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525,Department of Systems Biology
[4] Computational and Mathematical Biology Group,Department of Cellular and Molecular Pharmacology
[5] Grenoble F-38041,Department of Biology
[6] France,undefined
[7] Harvard Medical School,undefined
[8] Center for International Development and Harvard University,undefined
[9] Unit of Animal Genomics,undefined
[10] GIGA-R and Faculty of Veterinary Medicine,undefined
[11] University of Liege,undefined
[12] 4000 Liege,undefined
[13] Wallonia-Brussels Federation,undefined
[14] Belgium,undefined
[15] The MIT Media Lab,undefined
[16] Massachusetts Institute of Technology,undefined
[17] Howard Hughes Medical Institute,undefined
[18] University of California,undefined
[19] San Francisco,undefined
[20] and California Institute for Quantitative Biosciences,undefined
[21] Broad Institute of MIT and Harvard,undefined
[22] Howard Hughes Medical Institute,undefined
[23] Massachusetts Institute of Technology,undefined
[24] Present address: Laboratoire de Bioinformatique des Génomes et des Réseaux (BiGRe),undefined
[25] Campus Plaine,undefined
[26] Free University of Brussels,undefined
[27] 1050 Brussels,undefined
[28] Wallonia-Brussels Federation,undefined
[29] Belgium.,undefined
来源：
Nature | 2012年 / 487卷
关键词：
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学科分类号：
摘要：
Novel protein-coding genes can arise either from pre-existing genes or de novo; here it is shown that functional genes emerge de novo through transitory proto-genes generated by widespread translational activity in non-genic sequences.
引用
收藏
页码：370 / 374
页数：4
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