Proto-genes and de novo gene birth

被引：0

作者：

Anne-Ruxandra Carvunis

Thomas Rolland

Ilan Wapinski

Michael A. Calderwood

Muhammed A. Yildirim

Nicolas Simonis

Benoit Charloteaux

César A. Hidalgo

Justin Barbette

Balaji Santhanam

Gloria A. Brar

Jonathan S. Weissman

Aviv Regev

Nicolas Thierry-Mieg

Michael E. Cusick

Marc Vidal

机构：

[1] Dana-Farber Cancer Institute,Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology

[2] Harvard Medical School,Department of Genetics

[3] UJF-Grenoble 1/CNRS/TIMC-IMAG UMR 5525,Department of Systems Biology

[4] Computational and Mathematical Biology Group,Department of Cellular and Molecular Pharmacology

[5] Grenoble F-38041,Department of Biology

[6] France,undefined

[7] Harvard Medical School,undefined

[8] Center for International Development and Harvard University,undefined

[9] Unit of Animal Genomics,undefined

[10] GIGA-R and Faculty of Veterinary Medicine,undefined

[11] University of Liege,undefined

[12] 4000 Liege,undefined

[13] Wallonia-Brussels Federation,undefined

[14] Belgium,undefined

[15] The MIT Media Lab,undefined

[16] Massachusetts Institute of Technology,undefined

[17] Howard Hughes Medical Institute,undefined

[18] University of California,undefined

[19] San Francisco,undefined

[20] and California Institute for Quantitative Biosciences,undefined

[21] Broad Institute of MIT and Harvard,undefined

[22] Howard Hughes Medical Institute,undefined

[23] Massachusetts Institute of Technology,undefined

[24] Present address: Laboratoire de Bioinformatique des Génomes et des Réseaux (BiGRe),undefined

[25] Campus Plaine,undefined

[26] Free University of Brussels,undefined

[27] 1050 Brussels,undefined

[28] Wallonia-Brussels Federation,undefined

[29] Belgium.,undefined

来源：

Nature | 2012年 / 487卷

关键词：

D O I：

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学科分类号：

摘要：

Novel protein-coding genes can arise either from pre-existing genes or de novo; here it is shown that functional genes emerge de novo through transitory proto-genes generated by widespread translational activity in non-genic sequences.

引用

页码：370 / 374

页数：4

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