Association of XRCC1 polymorphisms with arsenic methylation

被引：0

作者：

Junko Fujihara

Toshihiro Yasuda

Hisato Iwata

Shinsuke Tanabe

Haruo Takeshita

机构：

[1] Shimane University School of Medicine,Department of Legal Medicine

[2] University of Fukui,Division of Medical Genetics and Biochemistry, Faculty of Medical Sciences

[3] Ehime University,Center for Marine Environmental Studies (CMES)

来源：

Archives of Toxicology | 2016年 / 90卷

关键词：

X-ray repair cross-complementing group 1 (XRCC1); Base excision repair (BER); Single nucleotide polymorphisms (SNPs); 8-Hydroxy-2′-deoxyguanosine (8-OHdG); Arsenic compounds;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2′-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100). Individuals with genotype AA in p.Pro206Pro showed significantly higher urinary monomethylarsonic acid (MMAV) and lower dimethylarsinic acid (DMAV)/MMAV ratio than genotype AG. As for p.Arg399Gln, both Arg/Arg homozygous subjects and Arg/Gln heterozygous individuals showed a significantly higher urinary inorganic As percentage and lower 8-OHdG concentrations than Gln/Gln homozygous. Our results suggested that Arg399Gln is a functional SNP that may be related to DNA repair activity.

引用

页码：1009 / 1012

页数：3

共 50 条

[31] Association studies of OGG1, XRCC1, XRCC2 and XRCC3 polymorphisms with differentiated thyroid cancer
Garcia-Quispes, Wilser-Andres
Perez-Machado, Giselle
Akdi, Abdelmounaim
Pastor, Susana
Galofre, Pere
Biarnes, Fina
Castell, Joan
Velazquez, Antonia
Marcos, Ricard
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2011, 709-10 : 67 - 72
[32] Association of RAD51, XRCC1, XRCC2, and XRCC3 Polymorphisms with Risk of Breast Cancer
Gupta, Priyanka
Sambyal, Vasudha
Guleria, Kamlesh
Uppal, Manjit Singh
Sudan, Meena
GENETIC TESTING AND MOLECULAR BIOMARKERS, 2023, 27 (07) : 205 - 214
[33] Association analysis of XRCC1 and XRCC3 polymorphisms with normal tissue reactions after pelvic irradiation
Encheva, E.
Lackov, T.
Yordanova, I.
Savov, A.
Kaneva, R.
Zahariev, Z.
Sultanov, B.
Kremensky, I.
Hadjieva, T.
EJC SUPPLEMENTS, 2008, 6 (09): : 152 - 152
[34] Association of the XRCC1 gene polymorphisms with cancer risk in Turkish breast cancer patients
Ugur Deligezer
Nejat Dalay
Experimental & Molecular Medicine, 2004, 36 : 572 - 575
[35] Association study between XRCC1 gene polymorphisms and sporadic amyotrophic lateral sclerosis
Coppede, Fabio
Migheli, Francesca
Lo Gerfo, Annalisa
Fabbrizi, Maria Rita
Carlesi, Cecilia
Mancuso, Michelangelo
Corti, Stefania
Mezzina, Nicoletta
del Bo, Roberto
Comi, Giacomo P.
Siciliano, Gabriele
Migliore, Lucia
AMYOTROPHIC LATERAL SCLEROSIS, 2010, 11 (1-2): : 122 - U30
[36] Association between XRCC1 and ERCC2 gene polymorphisms and development of osteosarcoma
Wang, Zimin
Wu, Na
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2016, 9 (01): : 223 - 229
[37] Association of XRCC1 gene polymorphisms with susceptibility to gastric cancer in Chinese Han population
Meng, Hua
Lu, Shuming
Zhang, Zhuqing
Chen, Meiru
Li, Chunyan
Liu, Lina
Luan, Yong
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2014, 66 (10) : 1463 - 1468
[38] Association of the XRCC1 gene polymorphisms with cancer risk in Turkish breast cancer patients
Deligezer, U
Dalay, N
EXPERIMENTAL AND MOLECULAR MEDICINE, 2004, 36 (06): : 572 - 575
[39] Genetic polymorphisms of XRCC1 and risk of gastric cancer
Lee, SG
Kim, B
Choi, JW
Kim, C
Lee, I
Song, K
CANCER LETTERS, 2002, 187 (1-2) : 53 - 60
[40] Genetic polymorphisms of XRCC1 and risk of the esophageal cancer
Lee, JM
Lee, YC
Yang, SY
Yang, PW
Luh, SP
Lee, CJ
Chen, CJ
Wu, MT
INTERNATIONAL JOURNAL OF CANCER, 2001, 95 (04) : 240 - 246

← 1 2 3 4 5 →