First spin-labeled cytisine derivatives

被引：0
|
作者：
Yu. F. Polienko
V. I. Vinogradova
Sh. Sh. Sagdullaev
N. D. Abdullaev
Yu. V. Gatilov
I. A. Grigor′ev
机构：
[1] Russian Academy of Sciences,N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch
[2] Academy of Sciences of the Republic of Uzbekistan,S. Yu. Yunusov Institute of the Chemistry of Plant Substances
来源：
Chemistry of Natural Compounds | 2013年 / 49卷
关键词：
cytisine; nitroxyl radicals; spin labels; LD50;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Spin-labeled cytisine derivatives containing stable pyrrolidine and piperidine nitroxyl radicals were synthesized by acylation and alkylation of the secondary amine. Toxicological studies showed that introduction of the nitroxyl group decreased significantly the general toxicity.
引用
收藏
页码：311 / 315
页数：4
相关论文
共 50 条
  • [31] Synthesis and biological evaluation of new spin-labeled derivatives of podophyllotoxin
    Jin, Y
    Chen, SW
    Tian, X
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (09) : 3062 - 3068
  • [32] STUDY ON ANTICANCER DRUGS——NEW SPIN-LABELED DERIVATIVES OF PODOPHYLLOTOXIN
    陈耀祖
    王彦广
    李景新
    田暄
    陈平
    [J]. Science Bulletin, 1990, (02) : 99 - 102
  • [33] STUDY ON ANTICANCER DRUGS - NEW SPIN-LABELED DERIVATIVES OF PODOPHYLLOTOXIN
    CHEN, YZ
    WANG, YG
    LI, JX
    TIAN, X
    CHEN, P
    [J]. CHINESE SCIENCE BULLETIN, 1990, 35 (02): : 99 - 102
  • [34] First synthesis of a fully active spin-labeled peptide hormone
    Barbosa, SR
    Cilli, EM
    Lamy-Freund, MT
    Castrucci, AML
    Nakaie, CR
    [J]. FEBS LETTERS, 1999, 446 (01): : 45 - 48
  • [35] INTERACTIONS OF SPIN-LABELED STEARIC ACIDS AND SPIN-LABELED LYSOPHOSPHOLIPIDS WITH CALMODULIN ACTIVATED BY CALCIUM
    SUZUKI, T
    UCHIDA, MK
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1987, 76 (11) : S57 - S57
  • [36] SPIN-LABELED COPPER PORPHYRINS
    STEMP, EDA
    EATON, GR
    EATON, SS
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1987, 193 : 19 - CHED
  • [37] SYNTHESIS OF SPIN-LABELED TRIAZENES
    RAIKOV, Z
    GADZHEVA, V
    KOCH, M
    KOLAR, G
    [J]. ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 1993, 25 (04) : 473 - 477
  • [38] ON THE EFFECTIVENESS OF SPIN-LABELED PROCAINE
    GOMBOSGAL, E
    LAKATOS, T
    TIGYI, J
    [J]. ACTA BIOCHIMICA ET BIOPHYSICA HUNGARICA, 1979, 14 (03) : 201 - 203
  • [39] Design, Synthesis and Biological Evaluation of Novel Spin-Labeled Derivatives of Podophyllotoxin
    Zhang, Jia-qiang
    Zhang, Zhi-wei
    Hui, Ling
    Tian, Xuan
    [J]. NATURAL PRODUCT COMMUNICATIONS, 2010, 5 (02) : 241 - 244
  • [40] Cytotoxicity of new stilbenoids from Pholidota chinensis and their spin-labeled derivatives
    Wu, Bin
    Qu, Haibin
    Cheng, Yiyu
    [J]. CHEMISTRY & BIODIVERSITY, 2008, 5 (09) : 1803 - 1810
12345