Single-molecule insights into surface-mediated homochirality in hierarchical peptide assembly

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作者
Yumin Chen
Ke Deng
Shengbin Lei
Rong Yang
Tong Li
Yuantong Gu
Yanlian Yang
Xiaohui Qiu
Chen Wang
机构
[1] National Center for Nanoscience and Technology,CAS Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Center for Excellence in Nanoscience
[2] China,Department of Chemistry, School of Science & Collaborative Innovation Center of Chemistry Science and Engineering (Tianjin)
[3] Tianjin University,School of Chemistry, Physics and Mechanical Engineering
[4] Queensland University of Technology,Fujian Institute of Research on the Structure of Matter
[5] Chinese Academy of Sciences,undefined
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Homochirality is very important in the formation of advanced biological structures, but the origin and evolution mechanisms of homochiral biological structures in complex hierarchical process is not clear at the single-molecule level. Here we demonstrate the single-molecule investigation of biological homochirality in the hierarchical peptide assembly, regarding symmetry break, chirality amplification, and chirality transmission. We find that homochirality can be triggered by the chirality unbalance of two adsorption configuration monomers. Co-assembly between these two adsorption configuration monomers is very critical for the formation of homochiral assemblies. The site-specific recognition is responsible for the subsequent homochirality amplification and transmission in their hierarchical assembly. These single-molecule insights open up inspired thoughts for understanding biological homochirality and have general implications for designing and fabricating artificial biomimetic hierarchical chiral materials.
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