Advances in understanding the molecular basis of frontotemporal dementia

Over the past decade, numerous studies have identified the causative genes and pathological proteins in most cases of frontotemporal dementia (FTD). Most recently, abnormal repeat expansion in theC9orf72 gene was identified as a major cause of the disorder. Rademakers et al. discuss how these discoveries have improved our understanding of the molecular basis of FTD, and highlight how these findings will translate into improved patient care.