An inverse relationship to germline transcription defines centromeric chromatin in C. elegans

被引:0
|
作者
Reto Gassmann
Andreas Rechtsteiner
Karen W. Yuen
Andrew Muroyama
Thea Egelhofer
Laura Gaydos
Francie Barron
Paul Maddox
Anthony Essex
Joost Monen
Sevinc Ercan
Jason D. Lieb
Karen Oegema
Susan Strome
Arshad Desai
机构
[1] Ludwig Institute for Cancer Research and Department of Cellular & Molecular Medicine University of California San Diego,Department of Molecular Cell and Developmental Biology
[2] University of California Santa Cruz,Department of Biology
[3] Carolina Center for Genome Sciences and Lineberger Comprehensive Cancer Center,undefined
[4] University of North Carolina at Chapel Hill,undefined
[5] Present addresses: School of Biological Sciences,undefined
[6] the University of Hong Kong,undefined
[7] Pokfulam,undefined
[8] Hong Kong (K.W.Y.); Department of Craniofacial Biology,undefined
[9] University of Colorado,undefined
[10] Health Sciences Center,undefined
[11] Aurora,undefined
[12] Colorado 80045,undefined
[13] USA (F.B.); Institute for Research in Immunology and Cancer,undefined
[14] Department of Pathology and Cell Biology,undefined
[15] University of Montreal,undefined
[16] Montreal,undefined
[17] Quebec H3C 3J7,undefined
[18] Canada (P.M.); The Salk Institute for Biological Studies,undefined
[19] San Diego,undefined
[20] California 92186,undefined
[21] USA (A.E.); Department of Neurobiology and Behavior,undefined
[22] Cornell University,undefined
[23] Ithaca,undefined
[24] New York 14853,undefined
[25] USA (J.M.).,undefined
来源
Nature | 2012年 / 484卷
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摘要
Centromere identity is thought to be epigenetically propagated by stable inheritance of nucleosomes containing the histone variant CENP-A; the authors propose a different model here in which germline transcription defines the genomic regions that exclude CENP-A incorporation during embryogenesis in the holocentric worm Caenorhabditis elegans.
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页码:534 / 537
页数:3
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