The efficacy and safety of SARS-CoV-2 vaccines mRNA1273 and BNT162b2 might be complicated by rampant C-to-U RNA editing

被引：0

作者：

Zhongzheng Bian

Ziqian Wu

Nan Liu

Xiao Jiang

机构：

[1] The Affiliated Hospital of Qingdao University,Department of Emergency Medicine

[2] The Affiliated Hospital of Qingdao University,Department of Emergency Intensive Care Unit

来源：

Journal of Applied Genetics | 2023年 / 64卷

关键词：

SARS-CoV-2; Vaccines; Synonymous codon usage; C-to-U RNA editing; Efficacy;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The SARS-CoV-2 RNA vaccines are smartly designed to increase the synonymous codon usage by introducing multiple U-to-C mutations. This design would elevate the translation efficiency of vaccine RNAs. However, we found evidence to reason that the designed cytidines might be converted to uridines again by C-to-U RNA deamination in host cells. This C-to-U mechanism might be a main factor that affects the efficacy and safety of RNA vaccines.

引用

页码：361 / 365

页数：4

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