Chromatin, gene silencing and HIV latency

被引：0
|
作者：
Hoi-Ping Mok
Andrew ML Lever
机构：
[1] University of Cambridge,Department of Medicine
[2] Addenbrooke's Hospital,undefined
来源：
Genome Biology | / 8卷
关键词：
Murine Leukemia Virus; Bovine Leukemia Virus; Human Immunodeficiency Virus; Human Immunodeficiency Virus Infection; Proviral Expression;
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摘要：
One of the cellular defenses against virus infection is the silencing of viral gene expression. There is evidence that at least two gene-silencing mechanisms are used against the human immuno-deficiency virus (HIV). Paradoxically, this cellular defense mechanism contributes to viral latency and persistence, and we review here the relationship of viral latency to gene-silencing mechanisms.
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