Chemical properties and immunotropic activity of the products from reaction of N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrimidinesulfone)-N′-isonicotinoylhydrazide with acids and bases in aqueous media

被引：0
|
作者：
E. S. Ryzhova
D. A. Panteleev
Yu. V. Chudetskaya
A. A. Volkov
N. B. Mel’nikova
M. V. Gulenova
V. K. Osmanov
A. V. Borisov
机构：
[1] Nizhni Novgorod State Medical Academy,
[2] Nizhni Novgorod State Technical University,undefined
来源：
Pharmaceutical Chemistry Journal | 2010年 / 44卷
关键词：
tautomerism; pyridine and pyrimidine derivatives; acid–base reactions; organic acids; hyaluronic acid; -(hydroxymethyl)aminomethane; triethanolamine; specific immunotropic activity;
D O I：
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中图分类号：
学科分类号：
摘要：
The effect of tautomerism on the structure of products from the reaction of N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrimidinesulfone)-N′-isonicotinoylhydrazide (kristafon) with acids (hydrochloric, phosphoric, acetic, oxalic, succinic, citric, hyaluronic) and bases [sodium hydroxide, triethanolamine, tris-(hydroxymethyl)aminomethane] in aqueous media has been studied using UV, IR, PMR, and 13C NMR spectroscopy techniques. The properties of kristafon are compared to those of analogous compounds containing pyridine (isonicotine hydrazide, sulfotolylisonicotine hydrazide) and pyrimidine [bis-p-(2,4-dioxo-6-methylpyrimidinyl-5-sulfonamino)-diphenylsulfone] fragments in acid–base media. It is shown that the immunotropic activity of kristafon phosphate and kristafon are improved in hyaluronic acid solution.
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页码：205 / 212
页数：7
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